Observations on muscle activity in REM sleep behavior disorder assessed with a semi-automated scoring algorithm

Rapid eye movement (REM) sleep behavior disorder (RBD) is a disorder defined by inappropriate muscle activity and enactment of dream content during REM sleep. RBD is closely connected with diseases pathologically characterized by abnormal aggregation of α-synuclein, including Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy (St Louis et al., 2017). RBD often precedes overt motor symptoms of α-synucleinopathies by years (Postuma et al., 2015b; St Louis et al., 2017), providing a window to study their early pre-motor and prodromal disease stages.

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