Simultaneous Integrated Boost for Radiation Dose Escalation to the Gross Tumor Volume with Intensity-Modulated (Photon) Radiation Therapy or Intensity-Modulated Proton Therapy and Concurrent Chemotherapy for Stage II-III Non-Small Cell Lung Cancer: A Phase I Study

Local failure is common after conventionally fractionated, standard-dose chemoradiation for NSCLC. Theoretically, higher doses could confer a survival benefit, but this has not been confirmed in a phase III trial using conventional techniques. Dose escalation by new strategies seems promising. Our study is trying to find the optimal dose and fractionation by image-guided IMRT or IMPT with a simultaneous integrated boost. This article presents our preliminary results of a phase I study.Simultaneous Integrated Boost for Radiation Dose Escalation to the Gross Tumor Volume with Intensity-Modulated (Photon) Radiation Therapy or Intensity-Modulated Proton Therapy and Concurrent Chemotherapy for Stage II-III Non-Small Cell Lung Cancer: A Phase I Study

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