Should Buprenorphine Be Administered to Patients With Opioid Withdrawal in the Emergency Department?

Of 3,573 studies identified, 27 met all inclusion criteria for meta-analysis: 6 studies evaluated buprenorphine versus tapered methadone, 7 evaluated tapering buprenorphine, and 14 evaluated buprenorphine versus α2-adrenergic agonists (primarily clonidine).

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