Man et al. show that hypoxia preferentially augments Notch signaling in glioma stem-like cells by inducing the HIF1/STAT3 target gene Vasorin. Vasorin functions as a competitive inhibitor of Numb to reduce Notch turnover, augmenting Notch signaling under hypoxic stress.
http://ift.tt/2Bo2saK
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
▼
2017
(44259)
- ► Δεκεμβρίου (5110)
-
▼
Νοεμβρίου
(5565)
-
▼
Νοε 30
(248)
- A new methanogen “Methanobrevibacter massiliense” ...
- Interleukin-35 Gene-Modified Mesenchymal Stem Cell...
- Gene Therapy for Modulation of T-Cell-Mediated Imm...
- Improvement of In Vivo Expression of Genes Deliver...
- Stereotype Threat Effects on Learning From a Cogni...
- Association of high cost sharing and targeted ther...
- CD90 Expression Controls Migration and Predicts Da...
- TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation...
- FDA Approval Summary: Rucaparib for the Treatment ...
- Therapeutic Drug Monitoring of Carboplatin in High...
- Phase III Clinical Trial (RERISE study) Results of...
- Phospholipase D1 Inhibition Linked to Upregulation...
- High BCR-ABL/GUSIS Levels at Diagnosis of Chronic ...
- BMP4 Induces M2 Macrophage Polarization and Favors...
- Immunomodulation by Entinostat in Renal Cell Carci...
- Tumor Heterogeneity Predicts Metastatic Potential ...
- A Novel Breast Cancer Index for Prediction of Dist...
- PAM50 Provides Prognostic Information When Applied...
- Correction: Myc Induces miRNA-Mediated Apoptosis i...
- Disparities in Prostate, Lung, Breast, and Colorec...
- Modeling Cytostatic and Cytotoxic Responses to New...
- Glutamine Addiction in Kidney Cancer Suppresses Ox...
- Integrated Analysis of Whole-Genome ChIP-Seq and R...
- EZH2 Modifies Sunitinib Resistance in Renal Cell C...
- Mesenchymal Stem Cells Promote Hepatocarcinogenesi...
- MYC Inhibition Depletes Cancer Stem-like Cells in ...
- IL10 Release upon PD-1 Blockade Sustains Immunosup...
- Administering xCT Inhibitors Based on Circadian Cl...
- Molecular regulation of Nodal signaling during mes...
- Optimization of Poplar mRNA purification for tranc...
- Paradoxical roles of TGF-β signaling in suppressin...
- A Naturalistic, Randomized Pilot Trial of E-Cigare...
- Mobile Screening Units for the Early Detection of ...
- Highlights of This Issue
- Aging-Related Disease Risks among Young Thyroid Ca...
- Blood Pressure Status in Adult Survivors of Childh...
- No Association of Waist Circumference and Prostate...
- Childhood Socioeconomic Position and Pubertal Onse...
- Emerging Trends in Family History of Breast Cancer...
- Biology and Etiology of Young-Onset Breast Cancers...
- Genetic Testing in a Population-Based Sample of Br...
- Metabolic Obesity Phenotypes and Risk of Breast Ca...
- Long-Term Effects of Weight Loss and Exercise on B...
- Alcohol, Physical Activity, Smoking, and Breast Ca...
- Impact of Patient-Provider Race, Ethnicity, and Ge...
- Healthcare System Distrust, Physician Trust, and P...
- Safety and Efficacy of Intratumoral Injections of ...
- Report on the Third FDA-AACR Oncology Dose-Finding...
- Characterization of Thyroid Disorders in Patients ...
- Differential Expression of Homing Receptor Ligands...
- Complex Immune Evasion Strategies in Classical Hod...
- Natural Killer T-cell Immunotherapy in Combination...
- Cisplatin Alters Antitumor Immunity and Synergizes...
- Interleukin-12 from CD103+ Batf3-Dependent Dendrit...
- Acknowledgment to Reviewers
- Fine-scale population genetic structure of arctic ...
- Co-infection with Bartonella bacilliformis and Myc...
- Type IV dual left anterior descending coronary art...
- Involuntary protection against dermatosis: A preli...
- Performance of MTBDRplus assay in detecting multid...
- Expert consensus on re-irradiation for recurrent g...
- Treatment of meningioma and glioma with protons an...
- Preoperative detection of pleural adhesions by res...
- Dissecting the heterogeneity of stage III non-smal...
- The optimal treatment of metastatic hormone-naive ...
- Overexpressed miR-128a enhances chemoradiotherapy ...
- Steroid-induced mental disorders in cancer patient...
- Perurethral transvesical route for oocytes retriev...
- Clinical significance of preoperative liver stiffn...
- Editorial Board
- Immunohistochemistry defined subtypes of breast ca...
- MicroRNA profile in HBV-induced infection and hepa...
- Standard-dose osimertinib for refractory leptomeni...
- Tumour budding in oral squamous cell carcinoma: a ...
- Analysis of the relationship between prescribed do...
- Peripheral neuropathy induced by microtubule-targe...
- Mutations in Homologous Recombination Genes and Ou...
- Blocking the Feedback Loop between Neuroendocrine ...
- Olaratumab exerts anti-tumor activity in preclinic...
- Whole exome sequencing of cell-free DNA reveals te...
- Surviving ovarian cancer: an affair between defect...
- Dasatinib Approved for Pediatric CML [News in Brief]
- Implementation of Moral Uncertainty in Intelligent...
- Clinical, morphologic, and demographic characteris...
- Drastic decrease of the HIV reservoir in a patient...
- Mesenteric cyst: an uncommon cause of acute abdomen
- Perioperative albumin ratio is associated with pos...
- How I do hanging manoeuvres to facilitate portal v...
- Utero-cutaneous fistula following Caesarean section
- Oesophageal adenocarcinoma associated with a right...
- Metastatic prostate cancer incidence in Australia ...
- Radical gastric cancer surgery results in widespre...
- Factors influencing lymph node skip metastasis in ...
- Hemodialysis Self-management Intervention Randomiz...
- Validity of a Risk Prediction Equation for CKD Aft...
- Caring for Undocumented Immigrants With Kidney Dis...
- Standard-dose osimertinib for refractory leptomeni...
- Tumour budding in oral squamous cell carcinoma: a ...
- A Nonlethal Case of Junctional Epidermolysis Bullo...
- Long-Term Outcomes of Hyperglycemic Preterm Infant...
-
▼
Νοε 30
(248)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 30 Νοεμβρίου 2017
Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.