Dye-Independent Methods Reveal Elevated Mitochondrial Mass in Hematopoietic Stem Cells

Snoeck and colleagues show that efflux of a mitochondrial content-reporting dye leads to the erroneous conclusion that HSCs have low mitochondrial content. Using alternative methodologies, they show that HSCs exhibit high mitochondrial content yet possess limited respiratory and turnover capacity. Mitochondria likely perform an essential yet unknown function in HSCs.

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