Cramps frequency and severity are correlated with small and large nerve fiber measures in type 1 diabetes

Muscle cramps are defined as sudden sustained and painful contraction of a muscle or muscle group. Muscle cramps are common, with a higher prevalence in the elderly(Abdulla et al. 1999) and in patients with neuropathic conditions,(Katzberg 2015) and are often underreported.(Naylor and Young 1994) The pathogenesis of muscle cramps involves spontaneous discharges of motor nerves, but the exact site of origin of these discharges, and their physiological mechanism remain uncertain.(Layzer 1994) Although the prevailing hypothesis is that muscle cramps originate and are propagated at motor nerves,(Layzer 1994) muscle cramps have also been described in sensory and pure small fiber neuropathies.(Lopate et al.

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