80. Small fiber neuropathy in Amyotrophic Lateral Sclerosis: Contribution of laser-evoked potentials and skin biopsy

Increasing evidence suggests that amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disorder, also determining a small fiber neuropathy (SFN) as recognized by skin biopsy studies in distal legs, irrespective of the disease duration. This study aimed at evaluating the performance of a battery of neurophysiological and morphological tests assessing the small fiber loss occurring in ALS.We recruited 10 consecutive ALS patients (5M, age 64.9±7.3, duration of symptoms 29.1±20.7months).

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