In reply to ‘Hynes et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study’

Abstract

In their recent paper ¹, Hynes et al. described the use of morphological features of the tumour microenvironment on H&E stained tissue sections for routine assessment of prognosis in stage II/III colon cancer patients. One of these features is the tumour stromal percentage (TSP), which was described by our group in 2007². Although we appreciate the fact that this method is widely used and validated, unfortunately Hynes and colleagues misinterpreted the method described by Mesker et al.

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