Pulmonary Invasive Mucinous Adenocarcinoma and Mixed Invasive Mucinous/Non-Mucinous Adenocarcinoma- A Clinicopathological and Molecular Genetic Study with Survival Analysis

Invasive mucinous adenocarcinoma is a variant of lung adenocarcinoma, which may be mixed with non-mucinous adenocarcinoma. KRAS mutations are common, but other clinical and genetic features are not clearly established. Lung adenocarcinomas (n=760) with ≥5years follow-up comprised 3 non-overlapping cohorts for survival analysis. Mucinous tumors were evaluated with Ion AmpliSeq™ Cancer Hotspot Panel v2. Cases without detected mutations were tested for ALK, ROS1, and by OncoScan array. Fifty-seven invasive mucinous adenocarcinomas and 54 mixed mucinous/non-mucinous adenocarcinomas were identified.

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