MicroRNA-139: a potential diagnostic and therapeutic target for cancers

MicroRNA-139-5p/3p (miR-139-5p/3p) and their different target genes have been reported to be associated with tumorigenesis by participating in multiple biological processes via the modulation of various aspects of cell biology, such as cell growth, proliferation and signal transduction. However, the miR-139-5p/3p expression signatures and function profiles in human breast cancer are still largely elusive. Surprisingly, we read with great interest the recently published work by Dai et al. [1], demonstrating that miR-139-5p tissue expression level is significantly down-regulated in breast cancer patients and correlated with higher tumor grade, estrogen receptor negativity, progesterone receptor negativity, greater proliferation, or larger size.

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