Repurposing thiram and disulfiram as antibacterial agents for multi-drug resistant Staphylococcus aureus infections [PublishAheadOfPrint]

Thiram and disulfiram were evaluated as antibacterial agents against multidrug resistant Staphylococcus aureus. Against a 30 member panel comprised of vancomycin-susceptible (VSSA), vancomycin-intermediate (VISA) and vancomycin-resistant (VRSA) strains, the MIC₉₀ values of the respective test agents were 4 and 16 μg/mL. Additional analyses revealed that thiram and disulfiram are rapid-acting bacteriostatic agents with narrow, Gram-positive bacteria spectrum activity. Synergy studies further determined that disulfiram increases the vancomycin susceptibility of three clinical VRSA strains in vitro, thus establishing a potential use in combination therapy.

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