A novel 6-benzyl ether benzoxaborole is active against Mycobacterium tuberculosis in vitro [PublishAheadOfPrint]

We identified a novel 6-benzyl ether benzoxaborole with potent activity against Mycobacterium tuberculosis. The compound had a minimum inhibitory concentration of 2 μM in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 μM and was active against intracellular bacteria (IC₅₀ = 3.6 μM) without cytotoxicity against eukaryotic cells (IC₅₀ >100 μM). We isolated resistant mutants (MIC ≥100 μM), which had mutations in Rv1683, Rv3068c and Rv0047c.

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