Prominent neural invasion of mucosal gastric cancer into the muscularis propria

Abstract

Neural invasion (NI) is one way of cancer spreading, and it is now considered a poor prognostic factor across the gastrointestinal tract malignancies including gastric cancer (GC).^{1, 2} NI occurs frequently and with greater severity in cholangiocarcinoma and pancreatic cancer in particular, which may contribute to the dismal prognoses in these cancers.¹ In the stomach, the nerve plexuses are concentrated in Meissner's plexus in the submucosa and Auerbach's plexus between the circular and longitudinal fibers of the muscularis propria.

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