(P002) Differential Expression of Microrna Between Standard Conventional Dose Versus Ablative Dose Radiation in Colorectal Cancer

The biologic heterogeneity of cancer confers a spectrum of radiation responsiveness warranting radiation dose escalation for certain cancers. However, clinicopathologic propensity for extensive microscopic spread negate strategies to reduce treatment volumes thus inhibiting safe dose escalation. A major regulator of the ionizing radiation (IR) response is microRNA (miR) with a critical function in cancer biology through their ability to regulate hundreds of genes in a gene network through differential sequence complementarity.

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