Different seizure-onset patterns in mesiotemporal lobe epilepsy have a distinct interictal signature

Different seizure-onset patterns (SOP) have been described in intracranial EEG. A recent meta-analysis demonstrated the variety of SOPs in focal epilepsy, and concluded that low-voltage fast activity (LVF) is overall the most common, whereas high-amplitude low-frequency periodic spiking (PS) is the most prevalent in mesiotemporal lobe epilepsy (mTLE) (Singh et al., 2015). In a large series of patients with refractory focal epilepsy due to different pathologies, our group identified seven different intracerebral SOPs (Perucca et al., 2014).

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