Publication date: Available online 27 July 2016
Source:Vaccine
Author(s): S. Ben-Shimol, D. Greenberg, N. Givon-Lavi, Y. Schlesinger, D. Miron, S. Aviner, R. Dagan
BackgroundThe worldwide introduction of pneumococcal conjugate vaccines (PCV) into National Immunization Programs resulted in rapid and substantial reduction of invasive pneumococcal disease (IPD) rates in children. However, the reduction of meningitis vs. non-meningitis IPD (nm-IPD) was not yet fully elucidated. We compared 7-valent and 13-valent PCV (PCV7 and PCV13) impact on pneumococcal-meningitis vs. nm-IPD in Israeli children <5years.MethodsWe conducted an ongoing nationwide, prospective, population-based, active surveillance. PCV7 and PCV13 were implemented in Israel in July 2009 and November 2010, respectively. All pneumococcal isolates (blood and/or CSF) from IPD episodes in children <5years from July 2000 through June 2015 were included. Extrapolation for missing serotypes (34.7% of all isolates) was conducted.Results4163 IPD cases were identified; 3739nm-IPD (89.8%) and 424 meningitis (10.2%). During the pre-PCV period (2000–2008), children <12months constituted 52.1% and 33.7% of meningitis and nm-IPD, respectively (p<0.001). The respective proportions of non-PCV13 serotypes (non-VT) were 18.2% vs. 10.1%, (p<0.001).Comparing the last study year (2014–2015) to the mean of pre-PCV period, meningitis incidence in children <5years decreased non-significantly by 27%, while nm-IPD decreased significantly by 69%. Dynamic rates of meningitis and nm-IPD caused by PCV13 serotypes were similar, with 93% and 95% overall reductions, respectively. However, non-VT increased in meningitis relatively to nm-IPD, mainly in children <24months. Serotype 12F rose sharply and significantly since 2009–2010 through 2014–2015 (28.6% of all non-VT meningitis in children <24m).ConclusionsThe overall impact of PCV7/PCV13 in children <5years in Israel was less prominent in meningitis than in nm-IPD. This could be attributed to the younger age of children with meningitis and differences in causative serotypes between the two groups, as the decline of the incidence of meningitis and nm-IPD caused by vaccine-serotypes is similar. Continuous monitoring of meningitis and nm-IPD is warranted.
http://ift.tt/2ayQdNb
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Ιουλίου
(489)
-
▼
Ιουλ 27
(49)
- Materials, Vol. 9, Pages 630: Fracture Properties ...
- Sensors, Vol. 16, Pages 1185: Monolithic Cylindric...
- Nutrients, Vol. 8, Pages 454: Validity and Reprodu...
- Nutrients, Vol. 8, Pages 458: Suppressive Effects ...
- Sensors, Vol. 16, Pages 1180: Object Detection App...
- Sensors, Vol. 16, Pages 1184: Three-Dimensional Ph...
- Sensors, Vol. 16, Pages 1182: Fast Object Motion E...
- IJERPH, Vol. 13, Pages 765: Endocrine Aspects of E...
- Sensors, Vol. 16, Pages 1181: Time-Varying Vocal F...
- Special Collection: Cell-Based Therapy for Bone Re...
- Study protocol for a randomised controlled trial t...
- Hundred top-cited articles focusing on acute kidne...
- Association of dental and periodontal disease with...
- Initial experience using a femtosecond laser catar...
- Sex differences in the risk profile of hypertensio...
- Special Collection: Cell-Based Therapy for Bone Re...
- Inside front cover
- Editorial Board
- Mercy Doc Appointed to National Academies' Quality...
- Mercy Gives $600,000 for Community Needs
- "Pokemon Go" is Latest Lesson in Digital Distractions
- Forming a Doctor-Patient Relationship
- Mercy Ranks in Top 5 Again and Again
- Sister’s Legacy Lives on through New Cancer Center
- More Hospitals Seek Software Support from Mercy
- Mercy Named Most Wired for 13th Time
- Beauty Queen’s Dream Still Alive
- Using Technology to Affect Influenza Vaccine Cover...
- Determination of Trace Water Content in Petroleum ...
- Fine needle aspiration cytology of cervical lymph ...
- CytoJournal Quiz Cases: Publishing open-access, Pu...
- Tuberculous lymphadenitis: Comparison of cytomorph...
- Contrasting female-male mortality ratios after rou...
- Changes in the anti-HBc profile of infants born to...
- Impact of PCV7/PCV13 introduction on invasive pneu...
- Complementary medicine and childhood immunisation:...
- Safety evaluation of adenovirus type 4 and type 7 ...
- To Your Health: NLM update: Salt linked to heart d...
- Molecular typing of human herpesvirus 8 among HIV ...
- The association between human papillomavirus (HPV)...
- Heterogeneous effects of oil shocks on exchange ra...
- Genotoxicity reduction in bagasse waste of sugar i...
- Cervical disc arthroplasty (CDA) versus anterior c...
- Establishing a framework to understand the regulat...
- To Your Health: NLM update: Exercise reduces cance...
- Endophenotype best practices
- Full title with Editorial board members
- Instructions to Authors
- IOP-details
-
▼
Ιουλ 27
(49)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.