The HIV-1 Gag p6 protein regulates the final abscission step of nascent virions from the cell membrane by the action of its two late (l-) domains, which recruit Tsg101 and ALIX, components of the ESCRT system. Even though p6 consists of only 52 amino acids, it is encoded by one of the most polymorphic regions of the HIV-1 gag gene and undergoes various posttranslational modifications including sumoylation, ubiquitination, and phosphorylation. In addition, it mediates the incorporation of the HIV-1 accessory protein Vpr into budding virions. Despite its small size, p6 exhibits an unusually high charge density. In this study, we show that mutation of the conserved glutamic acids within p6 increases the membrane association of Pr55 Gag followed by enhanced polyubiquitination and MHC-I antigen presentation of Gag-derived epitopes, possibly due to prolonged exposure to membrane bound E3 ligases. The replication capacity of the total glutamic acid mutant E0A was almost completely impaired, which was accompanied by defective virus release that could not be rescued by ALIX overexpression. Altogether, our data indicate that the glutamic acids within p6 contribute to the late steps of viral replication and may contribute to the interaction of Gag with the plasma membrane.
from #Medicine via ola Kala on Inoreader http://ift.tt/1YPFnTI
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Απριλίου
(500)
-
▼
Απρ 25
(50)
- Inorganics, Vol. 4, Pages 10: Adsorption of Water ...
- Metals, Vol. 6, Pages 97: Erratum: Wally, Z.J.; va...
- Micromachines, Vol. 7, Pages 75: Quasi-Optical Ter...
- Cells, Vol. 5, Pages 20: Role of Intermediate Fila...
- Elevated serum ferritin is associated with increas...
- Comparison of clinical efficacy and renal safety o...
- Potential role of the microbiome in Barrett’s esop...
- Benchmarking trial between France and Australia co...
- Role of percutaneous abscess drainage in the manag...
- Exploring hepatitis from the perspective of Irania...
- Does gastroesophageal reflux increase chronic obst...
- Mucosal pathobiology and molecular signature of ep...
- Clinicopathological characteristics of cancer asso...
- Similarities and differences among eosinophilic es...
- Molecular detection of H. pylori using adherent ga...
- Adverse events after radiofrequency ablation in pa...
- Ulcerative colitis patients With Clostridium diffi...
- Effect and safety of daclatasvir-asunaprevir combi...
- Effects of daily telephone-based re-education befo...
- ACG Clinical Guideline: Diagnosis, treatment, and ...
- Treatment with oxidized phospholipids directly inh...
- Hepatitis C virus resistance to direct-acting anti...
- Early nasojejunal tube feeding versus nil-by-mouth...
- An international consensus report on a new algorit...
- Insights into the morphology of symbiotic shrimp e...
- Nutrient uplift in a cyclonic eddy increases diver...
- Elevational variation in body-temperature response...
- Watch out where you sleep: nocturnal sleeping beha...
- PKC in motorneurons underlies self-learning, a for...
- Development of a stem taper equation and modelling...
- Ectopic expression of Jatropha curcas APETALA1 (Jc...
- Diversity improves performance in excitable networks
- GoPros™ as an underwater photogrammetry tool for c...
- Viruses, Vol. 8, Pages 117: Glutamic Acid Residues...
- Atmosphere, Vol. 7, Pages 62: Examining the Impact...
- Animals, Vol. 6, Pages 26: Cecil: A Moment or a Mo...
- Viruses, Vol. 8, Pages 107: Development of a Tripl...
- Toxins, Vol. 8, Pages 121: Dynamic Duo—The Salmone...
- Energies, Vol. 9, Pages 314: Economic Impact of In...
- Energies, Vol. 9, Pages 317: Power Production Loss...
- Energies, Vol. 9, Pages 311: Optimal Day-Ahead Sch...
- Energies, Vol. 9, Pages 312: Comparison of Dissolv...
- JCM, Vol. 5, Pages 49: Treatment of Established St...
- Nitric oxide synthase and changes in oxidative str...
- Elevated yolk progesterone moderates prenatal hear...
- Energies, Vol. 9, Pages 316: Solar Hydrogen Produc...
- Toxins, Vol. 8, Pages 121: Dynamic Duo—The Salmone...
- Biosensors, Vol. 6, Pages 18: Current-Induced Tran...
- Energies, Vol. 9, Pages 309: One-Dimensional Model...
- Micromachines, Vol. 7, Pages 73: Influence of Geom...
-
▼
Απρ 25
(50)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 25 Απριλίου 2016
Viruses, Vol. 8, Pages 117: Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.