Cystic fibrosis (CF) is the most frequent congenital lethal disease in Caucasians. Impaired mucociliary clearance causes chronic bacterial rhinosinusitis in up to 62% of patients, and almost all patients exhibit sinonasal pathology in CT scans. Pathogens like Pseudomonas aeruginosa (P.a.) chronically colonize about 70% of the CF adults' lungs and are the major reason for pulmonary destruction and premature death. In our 34-year-old female CF patient, rhinosinusitis caused massive orbital hypertelorism despite three sinonasal operations. Her sputum samples had always been negative for P.a. Then, P.a. was primarily detected in her sputum and additionally in nasal lavage, which since then persisted in both, her upper and lower airways. The P.a. strains turned out to be genetically identical in both airway levels, indicating early colonization of the entire airway system with P.a. This first report on simultaneous primary P.a. detection in the sinonasal and pulmonary compartments highlights the need to include an assessment of upper airway colonization in the standards of CF care, particularly in patients without chronic P.a. colonization. Both airway levels need to be considered as one united system, and a strong cooperation between ENT and CF specialists should be established. Prospective longitudinal studies should assess the upper airways´ role in acquisition and persistence of pathogens and evaluate conservative and surgical therapeutic options.
from #Medicine via ola Kala on Inoreader http://ift.tt/1WtmrcH
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαρτίου
(699)
-
▼
Μαρ 17
(50)
- Previewing the 21st John H.P. Maley Lecture
- Previewing the 47th Mary McMillan Lecture
- Catalysts, Vol. 6, Pages 47: Homo-Polymerization o...
- Sinusitis, Vol. 1, Pages 49-54: Chronic Rhinosinus...
- Inhibition of Asthma in OVA Sensitized Mice Model ...
- The Effectiveness of Cupping Therapy on Relieving ...
- Attentional guidance by relative features: Behavio...
- Emotional responses to irony and emoticons in writ...
- Symmetry, Vol. 8, Pages 15: Low Dimensional Vessio...
- Energies, Vol. 9, Pages 214: Application of Breath...
- Symmetry, Vol. 8, Pages 14: Status of X(1835) and ...
- Viruses, Vol. 8, Pages 82: Roles of the Picornavir...
- Polymers, Vol. 8, Pages 90: Preparation of Uniform...
- Energies, Vol. 9, Pages 215: Evaluation of a Mixed...
- Remote Sensing, Vol. 8, Pages 255: Remote Sensing ...
- Remote Sensing, Vol. 8, Pages 258: An Automatic Bu...
- Evaluation of the anti-inflammatory action of curc...
- Exploration of the P3 region of PEXEL peptidomimet...
- Identification of Small-Molecule Compounds Targeti...
- Single-cell Mass Spectrometry with Multi-solvent E...
- Quantification of Tunicamycin-Induced Protein Expr...
- Long-term changes in dysnatremia incidence in the ...
- Ann Agric Environ Med 2016; 23(1):79-83 "Relations...
- Ann Agric Environ Med 2016; 23(1):106-110 "Cytotox...
- Ann Agric Environ Med 2016; 23(1):30-36 "Microarra...
- Ann Agric Environ Med 2016; 23(1):157-162 "Opinion...
- Ann Agric Environ Med 2016; 23(1):37-43 "Obesity a...
- Ann Agric Environ Med 2016; 23(1):125-128 "Clinica...
- Ann Agric Environ Med 2016; 23(1):44-53 "Sublingua...
- Ann Agric Environ Med 2016; 23(1):182-192 "Augment...
- Metals, Vol. 6, Pages 68: NURBS-Based Collocation ...
- Materials, Vol. 9, Pages 207: Fatigue Life Predict...
- IJMS, Vol. 17, Pages 395: Intronic Polymorphisms i...
- Materials, Vol. 9, Pages 205: Computational Study ...
- Molecules, Vol. 21, Pages 363: Comparison of the P...
- Lubricants, Vol. 4, Pages 8: Tribological Behaviou...
- Sensors, Vol. 16, Pages 384: A Differential Monoli...
- Cloning and Expression of the γ-Polyglutamic Acid ...
- Changes in pigment, spectral transmission and elem...
- Sponge distribution and the presence of photosymbi...
- Omega-3 fatty acids shown to exert a positive effe...
- IJMS, Vol. 17, Pages 392: Spatial Temporal Dynamic...
- Sensors, Vol. 16, Pages 388: Node Deployment Algor...
- Molecules, Vol. 21, Pages 367: Pharmacokinetics of...
- Pathogens, Vol. 5, Pages 32: Evasion of Neutrophil...
- Molecules, Vol. 21, Pages 368: Binding Mode and Se...
- Molecules, Vol. 21, Pages 365: Silver Nanoparticle...
- Energies, Vol. 9, Pages 212: Exergy Flows inside a...
- Molecules, Vol. 21, Pages 362: Searching for Multi...
- Entropy, Vol. 18, Pages 102: Development of a Refr...
-
▼
Μαρ 17
(50)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 17 Μαρτίου 2016
Sinusitis, Vol. 1, Pages 49-54: Chronic Rhinosinusitis as a Crucial Symptom of Cystic Fibrosis—Case Report and Discussion on the Sinonasal Compartment as Site of Pseudomonas aeruginosa Acquisition into CF Airways
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.