Recent genome-wide association studies identified single nucleotide polymorphisms (SNPs) on the chromosome 9p21.3 conferring the risk for CAD (coronary artery disease) in individuals of Caucasian ancestry. We performed a genetic association study to investigate the effect of 12 candidate SNPs within 9p21.3 locus on the risk of CAD in the Saudi population of the Eastern Province of Saudi Arabia. A total of 250 Saudi CAD patients who had experienced an myocardial infarction (MI) and 252 Saudi age-matched healthy controls were genotyped using TaqMan assay. Controls with evidenced lack of CAD provided 90% of statistical power at the type I error rate of 0.05. Five percent of the results were rechecked for quality control using Sanger sequencing, the results of which concurred with the TaqMan genotyping results. Association analysis of 12 SNPs indicated a significant difference in the genotype distribution for four SNPs between cases and controls (rs564398 p = 0.0315, χ2 = 4.6, odds ratio (OD) = 1.5; rs4977574 p = 0.0336, χ2 = 4.5, OD = 1.4; rs2891168 p = 1.85 × 10 − 10, χ2 = 40.6, OD = 2.1 and rs1333042 p = 5.14 × 10 − 9, χ2 = 34.1, OD = 2.2). The study identified three protective haplotypes (TAAG p = 1.00 × 10 − 4; AGTA p = 0.022 and GGGCC p = 0.0175) and a risk haplotype (TGGA p = 2.86 × 10 − 10) for the development of CAD. This study is in line with others that indicated that the SNPs located in the intronic region of the CDKN2B-AS1 gene are associated with CAD.
from #Medicine via ola Kala on Inoreader http://ift.tt/1pNkmOj
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαρτίου
(699)
-
▼
Μαρ 17
(50)
- Previewing the 21st John H.P. Maley Lecture
- Previewing the 47th Mary McMillan Lecture
- Catalysts, Vol. 6, Pages 47: Homo-Polymerization o...
- Sinusitis, Vol. 1, Pages 49-54: Chronic Rhinosinus...
- Inhibition of Asthma in OVA Sensitized Mice Model ...
- The Effectiveness of Cupping Therapy on Relieving ...
- Attentional guidance by relative features: Behavio...
- Emotional responses to irony and emoticons in writ...
- Symmetry, Vol. 8, Pages 15: Low Dimensional Vessio...
- Energies, Vol. 9, Pages 214: Application of Breath...
- Symmetry, Vol. 8, Pages 14: Status of X(1835) and ...
- Viruses, Vol. 8, Pages 82: Roles of the Picornavir...
- Polymers, Vol. 8, Pages 90: Preparation of Uniform...
- Energies, Vol. 9, Pages 215: Evaluation of a Mixed...
- Remote Sensing, Vol. 8, Pages 255: Remote Sensing ...
- Remote Sensing, Vol. 8, Pages 258: An Automatic Bu...
- Evaluation of the anti-inflammatory action of curc...
- Exploration of the P3 region of PEXEL peptidomimet...
- Identification of Small-Molecule Compounds Targeti...
- Single-cell Mass Spectrometry with Multi-solvent E...
- Quantification of Tunicamycin-Induced Protein Expr...
- Long-term changes in dysnatremia incidence in the ...
- Ann Agric Environ Med 2016; 23(1):79-83 "Relations...
- Ann Agric Environ Med 2016; 23(1):106-110 "Cytotox...
- Ann Agric Environ Med 2016; 23(1):30-36 "Microarra...
- Ann Agric Environ Med 2016; 23(1):157-162 "Opinion...
- Ann Agric Environ Med 2016; 23(1):37-43 "Obesity a...
- Ann Agric Environ Med 2016; 23(1):125-128 "Clinica...
- Ann Agric Environ Med 2016; 23(1):44-53 "Sublingua...
- Ann Agric Environ Med 2016; 23(1):182-192 "Augment...
- Metals, Vol. 6, Pages 68: NURBS-Based Collocation ...
- Materials, Vol. 9, Pages 207: Fatigue Life Predict...
- IJMS, Vol. 17, Pages 395: Intronic Polymorphisms i...
- Materials, Vol. 9, Pages 205: Computational Study ...
- Molecules, Vol. 21, Pages 363: Comparison of the P...
- Lubricants, Vol. 4, Pages 8: Tribological Behaviou...
- Sensors, Vol. 16, Pages 384: A Differential Monoli...
- Cloning and Expression of the γ-Polyglutamic Acid ...
- Changes in pigment, spectral transmission and elem...
- Sponge distribution and the presence of photosymbi...
- Omega-3 fatty acids shown to exert a positive effe...
- IJMS, Vol. 17, Pages 392: Spatial Temporal Dynamic...
- Sensors, Vol. 16, Pages 388: Node Deployment Algor...
- Molecules, Vol. 21, Pages 367: Pharmacokinetics of...
- Pathogens, Vol. 5, Pages 32: Evasion of Neutrophil...
- Molecules, Vol. 21, Pages 368: Binding Mode and Se...
- Molecules, Vol. 21, Pages 365: Silver Nanoparticle...
- Energies, Vol. 9, Pages 212: Exergy Flows inside a...
- Molecules, Vol. 21, Pages 362: Searching for Multi...
- Entropy, Vol. 18, Pages 102: Development of a Refr...
-
▼
Μαρ 17
(50)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 17 Μαρτίου 2016
IJMS, Vol. 17, Pages 395: Intronic Polymorphisms in the CDKN2B-AS1 Gene Are Strongly Associated with the Risk of Myocardial Infarction and Coronary Artery Disease in the Saudi Population
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.