This study aimed at comparing bortezomib, thalidomide, and lenalidomide in patients with multiple myeloma (MM) for safety and efficacy using meta-analysis. This meta-analysis identified 17 randomized controlled trials (RCTs) including 6742 patients. These RCTs were separated according to the different agent-based regimens and to autologous stem-cell transplantation (ASCT). Complete response (CR), progression-free survival (PFS), overall survival (OS), and adverse events (AE) were combined. The total weighted risk ratio (RR) of CR was 3.29 [95% confidence interval (95% CI): 2.22–4.88] () for the novel agent-based regimens. These novel agent-based regimens showed greater benefit in terms of PFS of all subgroups irrespective of whether the patient received ASCT or not. The hazard ratio (HR) for PFS was 0.64 [95% CI: 0.60–0.69] (). Improvements of OS could be found only in the bortezomib- and thalidomide-based regimens without ASCT. The pooled HRs were 0.74 [95% CI: 0.65–0.86] () and 0.80 [95% CI: 0.70–0.90] (), respectively. Several AEs were shown more frequently in the novel agent-based regimens compared with controls such as hematologic events (neutropenia, anemia, and thrombocytopenia), gastrointestinal infection, peripheral neuropathy, thrombosis, and embolism events. In conclusion, in spite of the AEs, novel agent-based regimens are safe and effective for the treatment of MM.
from #Medicine via ola Kala on Inoreader http://ift.tt/1QBIlYY
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Φεβρουαρίου
(793)
-
▼
Φεβ 01
(50)
- High protein intake in young children and increase...
- Synthetic folic acid intakes and status in childre...
- Capsaicin-induced satiety is associated with gastr...
- Response to "Best (but oft forgotten) practices: t...
- Brain regulation of appetite in twins [Obesity and...
- Monitoring postnatal growth of preterm infants: pr...
- Comparison of the effect of daily consumption of p...
- Maternal anemia and risk of adverse birth and heal...
- Intakes of fish and polyunsaturated fatty acids an...
- Dietary flavonoid intake and incidence of erectile...
- Comparison of the DASH (Dietary Approaches to Stop...
- Interaction of methylation-related genetic variant...
- Exercise performed immediately after fructose inge...
- Title page and TOC [Supplement-Evaluating the Evid...
- The association between dietary saturated fatty ac...
- Dysphagia in the high-risk infant: potential facto...
- Myth-busting and fact-sharing about Family Medicine
- Technical Note: Independent component analysis for...
- High dose amoxicillin-based first line regimen is ...
- The correlation between Doppler US measurement of ...
- Laparoscopic treatment experience of severe acute ...
- Whole genome sequencing identified new somatic mut...
- MiR-874 inhibits cell growth and induces apoptosis...
- Clinical analysis on argon plasma coagulation (APC...
- Interleukin-17A inhibits cell autophagy under star...
- Clinical significance of serum protease activated ...
- Association of ABO and Rh blood groups with type 2...
- Evaluation of Atlas-Based Attenuation Correction f...
- Age-Related Sex-Specific Changes in Brain Metaboli...
- Molecular Imaging of Post-Src Inhibition Tumor Sig...
- In Vivo and In Vitro Characterization of a Novel M...
- Perfusion Imaging in Clinical Practice: A Multimod...
- Evaluation of 6-11C-Methyl-m-Tyrosine as a PET Pro...
- Synthesis and Preliminary Evaluation of Phenyl 4-1...
- Imaging the Impact of the P-Glycoprotein (ABCB1) F...
- PET Imaging of VEGFR-2 Expression in Lung Cancer w...
- Dynamic In Vivo SPECT Imaging of Neural Stem Cells...
- Efficacy and Safety of Novel Agent-Based Therapies...
- A comprehensive catalog of the lysine-acetylation ...
- Lipoxin A4 attenuates LPS-induced mouse acute lung...
- IJMS, Vol. 17, Pages 91: Biological Evaluation of ...
- IJMS, Vol. 17, Pages 193: The Role of Endoplasmic ...
- IJMS, Vol. 17, Pages 192: Pharmacological Modulato...
- IJMS, Vol. 17, Pages 191: Prioritization of Suscep...
- Climate envelope predictions indicate an enlarged ...
- Exploration of the “larval pool”: development and ...
- Estimating and comparing microbial diversity in th...
- IJMS, Vol. 17, Pages 193: The Role of Endoplasmic ...
- IJMS, Vol. 17, Pages 191: Prioritization of Suscep...
- IJMS, Vol. 17, Pages 192: Pharmacological Modulato...
-
▼
Φεβ 01
(50)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 1 Φεβρουαρίου 2016
Efficacy and Safety of Novel Agent-Based Therapies for Multiple Myeloma: A Meta-Analysis
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.