In this study an efficient and direct production procedure for a macrocyclic polyether N,N′-diallyl-7,16-diaza-1,4,10,13-tetraoxa-dibenzo-18-crown-6 from the reaction of catechol and N,N-bis(2-chloroethyl)prop-2-en-1-amine in n-butanol in the presence of a strong base is reported. The synthesis involves a two-step addition of sodium hydroxide to enhance the cyclization process, and at the end of the reaction, the reaction mixture is neutralized and the solvent replaced with water in-situ through distillation to afford a relatively pure precipitate that is easily recrystallized from acetone. The yield of the macrocycle was 36%–45% and could be scaled-up to one-mole quantities. The structure and purity of this compound was verified on the basis of elemental analysis, IR, UV-Vis, 1H-, 13C-NMR, 2D-NMR, mass spectroscopy, and thermal analysis. The white crystalline compound has a sharp melting point of 124 °C and a crystallization temperature of 81.4 °C determined by differential scanning calorimetry. Our motivation behind the synthesis of the bibracchial lariat azacrown polyether ligand was to examine its possible applications in ion-selective polymer-supported materials.
from #Medicine via ola Kala on Inoreader http://ift.tt/1UuW2tX
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
Ιανουαρίου
(578)
-
▼
Ιαν 29
(50)
- Ainhum or Dactylolysis Spontanea: a Missing Toe
- Thirty Six Views of Mount Fuji and the First Oncol...
- Assisted Reproductive Technology in Female Transpl...
- Ectopic Decidualization: A Forgotten Entity
- Are Amyotrophic Lateral Sclerosis Caregivers at Hi...
- Syphilis: Prevalence in a Hospital in Lisbon
- A Neurologist’s Hard Day’s Work: Impact of Inpatie...
- Prevalence of Pre-Obesity/Obesity in Pre and Basic...
- β-Tricalcium Phosphate in the Surgical Treatment o...
- Burnout in Portuguese Healthcare Professionals: An...
- Oncology Referral Concerning Paediatric Neurosurge...
- Analysis of the Cochrane Review: Incentives for Sm...
- Heart Failure: A New Epidemic of Cardiovascular Di...
- Thank You, Reviewers of Acta Médica Portuguesa
- General Practitioner Sentinel Network as a Tool of...
- Life, Vol. 6, Pages 7: Regulation of Expression an...
- A photo-cleavable biotin affinity tag for the faci...
- Synthesis and cytotoxicity of thieno[2,3-b]quinoli...
- Design, Synthesis and Biological Evaluation of Din...
- Synthesis and Biological Evaluation of Novel Inhib...
- Micromachines, Vol. 7, Pages 22: CD-Based Microflu...
- Regulation of endothelial dynamics by PGC-1α relie...
- Effect of the SOD mimetic MnL4 on in vitro and in ...
- Physical exercise, reactive oxygen species and neu...
- Case Report of Cirrhosis following Yttrium-90 Radi...
- Medicines, Vol. 3, Pages 5: The Effects of Yin, Ya...
- Metals, Vol. 6, Pages 29: Effect of Laser Surface ...
- Quantitative electrochemical metalloimmunoassay fo...
- Molecules, Vol. 21, Pages 171: Synthesis and Chara...
- Molecules, Vol. 21, Pages 167: Insight of Saffron ...
- Langerhans Cell Histiocytosis of the Rib in an Adu...
- Atmosphere, Vol. 7, Pages 18: Solar Forecasting in...
- Water, Vol. 8, Pages 42: Using a Geospatial Model ...
- Polymers, Vol. 8, Pages 37: Investigations of the ...
- IJMS, Vol. 17, Pages 178: Induction of Apoptosis b...
- IJMS, Vol. 17, Pages 179: Plasma Monocyte Chemoatt...
- IJMS, Vol. 17, Pages 176: Melatonin Suppresses the...
- IJMS, Vol. 17, Pages 180: Clinical Genetic Aspects...
- IJMS, Vol. 17, Pages 177: Ginsenoside-Rd Promotes ...
- IJMS, Vol. 17, Pages 182: miR-30-5p Regulates Musc...
- IJMS, Vol. 17, Pages 182: miR-30-5p Regulates Musc...
- Nutrients, Vol. 8, Pages 73: Resveratrol Supplemen...
- IJMS, Vol. 17, Pages 179: Plasma Monocyte Chemoatt...
- Animals, Vol. 6, Pages 9: Heat Tolerance in Curral...
- Polymers, Vol. 8, Pages 22: Artificial Neural Netw...
- Nutrients, Vol. 8, Pages 72: Supplementation with ...
- Polymers, Vol. 8, Pages 36: l-Cystine-Crosslinked ...
- Mitochondrial calcium uniporter opener spermine at...
- IJMS, Vol. 17, Pages 176: Melatonin Suppresses the...
- Forests, Vol. 7, Pages 32: Developing Aboveground ...
-
▼
Ιαν 29
(50)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 29 Ιανουαρίου 2016
Molecules, Vol. 21, Pages 171: Synthesis and Characterization of Macrocyclic Polyether N,N′-Diallyl-7,16-diaza-1,4,10,13-tetraoxa-dibenzo-18-crown-6
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.