Panax ginseng is a famous herbal medicine widely used in Asia. Ginsenosides have been identified as the principle active ingredients for Panax ginseng's biological activity, among which ginsenoside Rd (Rd) attracts extensive attention for its obvious neuroprotective activities. Here we investigated the effect of Rd on neurite outgrowth, a crucial process associated with neuronal repair. PC12 cells, which respond to nerve growth factor (NGF) and serve as a model for neuronal cells, were treated with different concentrations of Rd, and then their neurite outgrowth was evaluated. Our results showed that 10 μM Rd significantly increased the percentages of long neurite- and branching neurite-bearing cells, compared with respective controls. The length of the longest neurites and the total length of neurites in Rd-treated PC12 cells were much longer than that of respective controls. We also showed that Rd activated ERK1/2 and AKT but not PKC signalings, and inhibition of ERK1/2 by PD98059 or/and AKT by LY294002 effectively attenuated Rd-induced neurite outgrowth. Moreover, Rd upregulated the expression of GAP-43, a neuron-specific protein involved in neurite outgrowth, while PD98059 or/and LY294002 decreased Rd-induced increased GAP-43 expression. Taken together, our results provided the first evidence that Rd may promote the neurite outgrowth of PC12 cells by upregulating GAP-43 expression via ERK- and ARK-dependent signaling pathways.
from #Medicine via ola Kala on Inoreader http://ift.tt/1JKQwD2
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
Ιανουαρίου
(578)
-
▼
Ιαν 29
(50)
- Ainhum or Dactylolysis Spontanea: a Missing Toe
- Thirty Six Views of Mount Fuji and the First Oncol...
- Assisted Reproductive Technology in Female Transpl...
- Ectopic Decidualization: A Forgotten Entity
- Are Amyotrophic Lateral Sclerosis Caregivers at Hi...
- Syphilis: Prevalence in a Hospital in Lisbon
- A Neurologist’s Hard Day’s Work: Impact of Inpatie...
- Prevalence of Pre-Obesity/Obesity in Pre and Basic...
- β-Tricalcium Phosphate in the Surgical Treatment o...
- Burnout in Portuguese Healthcare Professionals: An...
- Oncology Referral Concerning Paediatric Neurosurge...
- Analysis of the Cochrane Review: Incentives for Sm...
- Heart Failure: A New Epidemic of Cardiovascular Di...
- Thank You, Reviewers of Acta Médica Portuguesa
- General Practitioner Sentinel Network as a Tool of...
- Life, Vol. 6, Pages 7: Regulation of Expression an...
- A photo-cleavable biotin affinity tag for the faci...
- Synthesis and cytotoxicity of thieno[2,3-b]quinoli...
- Design, Synthesis and Biological Evaluation of Din...
- Synthesis and Biological Evaluation of Novel Inhib...
- Micromachines, Vol. 7, Pages 22: CD-Based Microflu...
- Regulation of endothelial dynamics by PGC-1α relie...
- Effect of the SOD mimetic MnL4 on in vitro and in ...
- Physical exercise, reactive oxygen species and neu...
- Case Report of Cirrhosis following Yttrium-90 Radi...
- Medicines, Vol. 3, Pages 5: The Effects of Yin, Ya...
- Metals, Vol. 6, Pages 29: Effect of Laser Surface ...
- Quantitative electrochemical metalloimmunoassay fo...
- Molecules, Vol. 21, Pages 171: Synthesis and Chara...
- Molecules, Vol. 21, Pages 167: Insight of Saffron ...
- Langerhans Cell Histiocytosis of the Rib in an Adu...
- Atmosphere, Vol. 7, Pages 18: Solar Forecasting in...
- Water, Vol. 8, Pages 42: Using a Geospatial Model ...
- Polymers, Vol. 8, Pages 37: Investigations of the ...
- IJMS, Vol. 17, Pages 178: Induction of Apoptosis b...
- IJMS, Vol. 17, Pages 179: Plasma Monocyte Chemoatt...
- IJMS, Vol. 17, Pages 176: Melatonin Suppresses the...
- IJMS, Vol. 17, Pages 180: Clinical Genetic Aspects...
- IJMS, Vol. 17, Pages 177: Ginsenoside-Rd Promotes ...
- IJMS, Vol. 17, Pages 182: miR-30-5p Regulates Musc...
- IJMS, Vol. 17, Pages 182: miR-30-5p Regulates Musc...
- Nutrients, Vol. 8, Pages 73: Resveratrol Supplemen...
- IJMS, Vol. 17, Pages 179: Plasma Monocyte Chemoatt...
- Animals, Vol. 6, Pages 9: Heat Tolerance in Curral...
- Polymers, Vol. 8, Pages 22: Artificial Neural Netw...
- Nutrients, Vol. 8, Pages 72: Supplementation with ...
- Polymers, Vol. 8, Pages 36: l-Cystine-Crosslinked ...
- Mitochondrial calcium uniporter opener spermine at...
- IJMS, Vol. 17, Pages 176: Melatonin Suppresses the...
- Forests, Vol. 7, Pages 32: Developing Aboveground ...
-
▼
Ιαν 29
(50)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 29 Ιανουαρίου 2016
IJMS, Vol. 17, Pages 177: Ginsenoside-Rd Promotes Neurite Outgrowth of PC12 Cells through MAPK/ERK- and PI3K/AKT-Dependent Pathways
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.