Objective: Cardiac surgery and postoperative admission to the ICU may lead to posttraumatic stress disorder and depression. Perioperatively administered corticosteroids potentially alter the risk of development of these psychiatric conditions, by affecting the hypothalamic-pituitary-adrenal axis. However, findings of previous studies are inconsistent. We aimed to assess the effect of a single dose of dexamethasone compared with placebo on symptoms of posttraumatic stress disorder and depression and health-related quality of life after cardiac surgery and ICU admission. Design: Follow-up study of a randomized clinical trial. Setting: Five Dutch heart centers. Patients: Cardiac surgery patients (n = 1,244) who participated in the Dexamethasone for Cardiac Surgery trial. Interventions: A single intraoperative IV dose of dexamethasone or placebo was administered in a randomized, double-blind way. Measurements and Main Results: Symptoms of posttraumatic stress disorder, depression, and health-related quality of life were assessed with validated questionnaires 1.5 years after randomization. Data were available for 1,125 patients (90.4%); of which 561 patients received dexamethasone and 564 patients received placebo. Overall, the prevalence of psychopathology was not influenced by dexamethasone. Posttraumatic stress disorder and depression were present in, respectively, 52 patients (9.3%) and 69 patients (12.3%) who received dexamethasone and in 66 patients (11.7%) and 78 patients (13.8%) who received placebo (posttraumatic stress disorder: odds ratio, 0.82; 95% CI, 0.55-1.20; p = 0.30; depression: odds ratio, 0.92; 95% CI, 0.64-1.31; p = 0.63). Subgroup analysis revealed a lower prevalence of posttraumatic stress disorder (odds ratio, 0.23; 95% CI, 0.07-0.72; p
from #Medicine via ola Kala on Inoreader http://ift.tt/1L05tux
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 05
(50)
- Editorial Board/Aims and Scope
- Prospective on multiscale simulation of virus-like...
- Soluble Urokinase Receptor and Chronic Kidney Disease
- Influence of Serum and Hypoxia on Incorporation of...
- Dietary ALA from Spinach Enhances Liver n-3 Fatty ...
- Two stages of XRCC1 recruitment and two classes of...
- Modulation of DNA damage responseand induction of ...
- Cadmium treatment suppresses DNA polymerase δ cata...
- Versatility in phospho-dependent molecular recogni...
- Role of mismatch repair proteins in the processing...
- In vitro chromatin templates to study nucleotide e...
- Historical perspective on the DNA damage response
- Evelyn Witkin and the Coordinated Response to DNA ...
- Design, synthesis, and characterization of nucleos...
- Evaluation of leishmanicidal activity and cytotoxi...
- Prevalence of intestinal parasites among patients ...
- Photolithographic Synthesis of High-Density DNA an...
- Tracking the Invasion of Small Numbers of Cells in...
- Elasto-Inertial Pinched Flow Fractionation for Con...
- Conditions Affecting Social Space in Drosophila me...
- Synthesis and Functionalization of 3D Nano-graphen...
- Preventing ICU Subsyndromal Delirium Conversion to...
- Economic Evaluation of Telemedicine for Patients i...
- Comparison Between Neurally Adjusted Ventilatory A...
- A Dysregulated Balance of Proinflammatory and Anti...
- Interleukin-17A Is Associated With Alveolar Inflam...
- Evaluation Following Staggered Implementation of t...
- The Effect of Dexamethasone on Symptoms of Posttra...
- Protective Effect of Areca catechu Leaf Ethanol Ex...
- Serum 25-Hydroxyvitamin D and Osteoarthritis in Ol...
- Total error vs. measurement uncertainty: revolutio...
- Selective extraction and determination of fluoroqu...
- Assessing similarity analysis of chromatographic f...
- Determination of d -serine in human serum by LC-MS...
- Determination of Effective Stability Constants of ...
- Chronic Intermittent Hypoxia and Blood Pressure: I...
- IFN-γ Induces Mimic Extracellular Trap Cell Death ...
- Special Collection: Emerging Concepts in Three-Dim...
- Serum 25-Hydroxyvitamin D and Osteoarthritis in Ol...
- Chronic Intermittent Hypoxia and Blood Pressure: I...
- Dielectric Barrier Discharge Ionization of Perfluo...
- Label-Free and Sensitive Detection of Thrombomodul...
- A J-shaped relationship between caloric intake and...
- Low Resolution Data-Independent Acquisition in an ...
- Video 3. Incorrectly Predicted Transitions During ...
- Video 2. Correctly Predicted Transitions During Re...
- Video 1. Ambulation Mode Transitions Using a Power...
- Ocular Movements, Heel-to-Shin Test, and Gait Asse...
- Simultaneous Electrodialytic Preconcentration and ...
- Surfactant modulated aggregation induced enhanceme...
-
▼
Νοε 05
(50)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.