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Πέμπτη 5 Νοεμβρίου 2015

Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage

Publication date: Available online 19 October 2015
Source:DNA Repair
Author(s): John-Stephen Taylor
How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic studies.

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