Ischemia-activated microglia are like a double-edged sword, characterized by both neurotoxic and neuroprotective effects. The aim of this study was to reveal the synergistic effect of geniposide and ginsenoside Rg1 based on tumor necrosis factor- (TNF-) α and transforming growth factor- (TGF-) β1 balance of microglia. BV2 microglial cells were divided into 5 groups: control, model (oxygen-glucose deprivation (OGD)), geniposide-treated, ginsenoside-Rg1-treated, and combination-treated. A series of assays were used to detect on (i) cell viability; (ii) NO content; (iii) expression (content) of TNF-α and TGF-β1; and (iv) gene expression profiles. The results showed that integrated use of geniposide and ginsenoside Rg1 significantly inhibited NO level and protected cell viability, improved the content and expression of TGF-β1, and reduced the content and expression of TNF-α. Separated use of geniposide or ginsenoside Rg1 showed different effects at different emphases. Next-generation sequencing showed that Fcγ-receptor-mediated phagocytosis pathway played a key regulatory role in the balance of TNF-α and TGF-β1 when cotreated with geniposide and ginsenoside Rg1. These findings suggest that synergistic drug combination of geniposide and ginsenoside Rg1 in the treatment of stroke is a feasible avenue for the application.
from #Medicine via ola Kala on Inoreader http://ift.tt/1Q6eiJE
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 29
(26)
- Orienting versus inhibition in the Concealed Infor...
- ECsafeSEAFOOD Seminar on the Island of Frøya in Ma...
- Comparison of the effect of W shaped skin incision...
- Corrigendum to “Enamel thickness trends in Plio-Pl...
- Retinal thickness and optic disc-to-fovea angle
- An Evolutionary Perspective of Nutrition and Infla...
- Flavonolignan 2,3-dehydroderivatives: Preparation,...
- Pre-treatment of rats with ad-hepcidin prevents ir...
- Citron Rho-interacting kinase mediates arsenite-in...
- Rat Model of Photochemically-Induced Posterior Isc...
- When the brain does not adequately feel the body: ...
- A smaller magnitude of exercise-induced hypoalgesi...
- QT Interval Variability Index and QT Interval Dura...
- Perinatal Health Statistics as the Basis for Perin...
- Dopamine D2 Receptor Is Involved in Alleviation of...
- Association between Plasma Leptin and Estrogen in ...
- An investigation on the simultaneously recorded oc...
- Synergistic Use of Geniposide and Ginsenoside Rg1 ...
- The Antioxidant and Starch Hydrolase Inhibitory Ac...
- Identification of Proteins Implicated in the Incre...
- Nonpharmacological Interventions to Reduce Behavio...
- Oxidative Stress in Placenta: Health and Diseases
- Effects of Bee Venom Injections at Acupoints on Ne...
- Alternatives to Transplantation in the Treatment o...
- Comment on “Is There a Risk of Yellow Fever Virus ...
- Anatomical Study of Intrahemispheric Association F...
-
▼
Νοε 29
(26)
Αναζήτηση αυτού του ιστολογίου
Κυριακή 29 Νοεμβρίου 2015
Synergistic Use of Geniposide and Ginsenoside Rg1 Balance Microglial TNF- and TGF-1 following Oxygen-Glucose Deprivation In Vitro: A Genome-Wide Survey
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.