The present study tries to identify proteins implicated in bradycardia rabbits in hearts after ShenSongYangXin (SSYX, a traditional Chinese medicine) treatment. Eighteen adult rabbits were randomly assigned to three groups: sham, model, and SSYX treatment groups. Heart rate was recorded in rabbits and proteins were isolated from ventricular muscle. We used isobaric tags for elative and absolute quantitation (iTRAQ) coupled with two-dimensional liquid chromatography-tandem mass spectrometry to identify altered proteins after SSYX treatment. The heart rate decreased after six weeks due to the injury of the sinoatrial node in the model group. This effect was partially reversed by 4-week SSYX treatment. A total of a2988 proteins were quantified by performing the iTRAQ-based experiments. Of these, 94 proteins were differentially expressed according to our criteria (49 upregulated and 45 downregulated). The identification of key proteins implicated in the treatment of bradycardia could serve as a foundation to better understand and further explore the molecular mechanism of SSYX treatment.
from #Medicine via ola Kala on Inoreader http://ift.tt/1XoZZWE
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 29
(26)
- Orienting versus inhibition in the Concealed Infor...
- ECsafeSEAFOOD Seminar on the Island of Frøya in Ma...
- Comparison of the effect of W shaped skin incision...
- Corrigendum to “Enamel thickness trends in Plio-Pl...
- Retinal thickness and optic disc-to-fovea angle
- An Evolutionary Perspective of Nutrition and Infla...
- Flavonolignan 2,3-dehydroderivatives: Preparation,...
- Pre-treatment of rats with ad-hepcidin prevents ir...
- Citron Rho-interacting kinase mediates arsenite-in...
- Rat Model of Photochemically-Induced Posterior Isc...
- When the brain does not adequately feel the body: ...
- A smaller magnitude of exercise-induced hypoalgesi...
- QT Interval Variability Index and QT Interval Dura...
- Perinatal Health Statistics as the Basis for Perin...
- Dopamine D2 Receptor Is Involved in Alleviation of...
- Association between Plasma Leptin and Estrogen in ...
- An investigation on the simultaneously recorded oc...
- Synergistic Use of Geniposide and Ginsenoside Rg1 ...
- The Antioxidant and Starch Hydrolase Inhibitory Ac...
- Identification of Proteins Implicated in the Incre...
- Nonpharmacological Interventions to Reduce Behavio...
- Oxidative Stress in Placenta: Health and Diseases
- Effects of Bee Venom Injections at Acupoints on Ne...
- Alternatives to Transplantation in the Treatment o...
- Comment on “Is There a Risk of Yellow Fever Virus ...
- Anatomical Study of Intrahemispheric Association F...
-
▼
Νοε 29
(26)
Αναζήτηση αυτού του ιστολογίου
Κυριακή 29 Νοεμβρίου 2015
Identification of Proteins Implicated in the Increased Heart Rate in ShenSongYangXin-Treated Bradycardia Rabbits by iTRAQ-Based Quantitative Proteomics
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.