Reducing sitting time after stroke. A Phase II safety and feasibility randomised controlled trial

Publication date: Available online 31 October 2015
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Coralie English, Genevieve N. Healy, Tim Olds, Gaynor Parfitt, Erika Borkoles, Alison Coates, Sharon Kramer, Julie Bernhardt
ObjectiveTo test the safety, feasibility and effectiveness of reducing sitting time in stroke survivors.DesignRandomised controlled trial with attention-matched control and blinded assessments.SettingCommunityParticipantsThirty-five stroke survivors (22 male, mean age 66.9 ± 12.7 years).InterventionsFour counselling sessions over seven weeks with a message of 'sit less, move more' (intervention group) or 'calcium for bone health' (attention-matched control group).Main outcome measuresSafety (adverse events, increases in pain, spasticity or fatigue) and feasibility (adherence to trial protocol). Secondary measures included time spent sitting (including in prolonged bouts ≥30mins), standing, and stepping as measured by the thigh-worn activPAL3 activity monitor (7 days, 24hrs/day protocol) and time spent in physical activity of at least moderate intensity as measured by the actigraph GT3x+. The Multi-Media Activity Recall for Children and Adults (MARCA) was used to describe changes in use-of-time.ResultsThirty-three participants completed the full protocol. Four participants reported falls during the intervention period with no other adverse events. From a baseline average of 640.7 (SD 99.6) min/day, daily sitting time reduced on average by 30.0 (SD 50.6) min/day (95% CI 5.8 to 54.6) in the intervention group and 40.4 (SD 92.5) min/day in the control group (95% CI 13.0 to 93.8). Participants in both groups also reduced their time spent in prolonged sitting bouts (≥30 minutes) and increased time spent standing and stepping.ConclusionsOur protocol was both safe and feasible. Participants in both groups spent less time sitting and more time standing and stepping post-intervention, but outcomes were not superior for intervention participants. Attention-matching is desirable in clinical trials, and may have contributed to the positive outcomes for control participants.



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