Cardiovascular diseases remain the main cause of mortality and morbidity worldwide; primary prevention is a priority for physicians. Biomarkers are useful tools able to identify high-risk individuals, guide treatments, and determine prognosis. Our aim is to investigate Endogenous Ouabain (EO), an adrenal stress hormone with hemodynamic effects, as a valuable biomarker of heart failure. In a population of 845 patients undergoing elective cardiac surgery, we have investigated the relationships between EO and echocardiography parameters/plasmatic biomarker of cardiac function. EO was found to be correlated negatively with left ventricular EF (), positively with Cardiac End-Diastolic Diameter (), and positively with plasmatic NT-proBNP level (). Moreover, a different plasmatic EO level (both preoperative and postoperative) was found according to NYHA class (). All these results have been replicated on an independent cohort of patients (147 subjects from US). Finally, a higher EO level in the immediate postoperative time was indicative of a more severe cardiological condition and it was associated with increased perioperative mortality risk ( for 30-day morality). Our data suggest that preoperative and postoperative plasmatic EO level identifies patients with a more severe cardiovascular presentation at baseline. These patients have a higher risk of morbidity and mortality after cardiac surgery.
from #Medicine via ola Kala on Inoreader http://ift.tt/1l1BNbm
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 01
(31)
- Therapeutic effects of inorganic nitrate and nitri...
- Intake of Meals Containing High Levels of Carbohyd...
- Production of high titer attenuated poliovirus str...
- Pediatric provider vaccine hesitancy: An under-rec...
- Non-thermal plasma for inactivated-vaccine prepara...
- Assessment of the enhancement of PLGA nanoparticle...
- Intranasal immunisation with recombinant adenoviru...
- Randomized comparison of the safety of Flublok® ve...
- Incidence of invasive pneumococcal disease in 5–15...
- The bm12 Inducible Model of Systemic Lupus Erythem...
- Strength training, but not endurance training, red...
- Factors to consider in identifying critical points...
- Nanoparticle Probes for Structural and Functional ...
- Reducing sitting time after stroke. A Phase II saf...
- A Cross-Sectional Examination of the Associations ...
- Isoflurane Damages the Developing Brain of Mice an...
- Prognostic Significance of the Tumor-Stroma Ratio ...
- Effectiveness and Safety of Manufactured Chinese H...
- The Combination of Resveratrol and Quercetin Atten...
- MR Prediction of Liver Function and Pathology Usin...
- Magnetic Resonance Imaging as a Biomarker for Rena...
- Endogenous Ouabain: An Old Cardiotonic Steroid as ...
- Novel Sensor-Enabled Ex Vivo Bioreactor: A New App...
- Coevolution between Cancer Activities and Food Str...
- Upconversion nanosensor for sensitive fluorescence...
- Metabolomic profile related to cardiovascular dise...
- Synthesis and Biological Profiling of 6- or 7-(Het...
- Synthesis and Evaluation of 3-Hydroxy-3-phenylprop...
- Big Data and Network Biology 2015
- Synergistic Effects of BMP9 and miR-548d-5p on Pro...
- Interoceptive awareness in patients with functiona...
-
▼
Νοε 01
(31)
Αναζήτηση αυτού του ιστολογίου
Κυριακή 1 Νοεμβρίου 2015
Endogenous Ouabain: An Old Cardiotonic Steroid as a New Biomarker of Heart Failure and a Predictor of Mortality after Cardiac Surgery
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.