We recently demonstrated that the CAV1 gene was down-regulated, when poorly differentiated thyroid FTC-133 cancer cells formed spheroids under simulated microgravity conditions. Here, we present evidence that the caveolin-1 protein is involved in the inhibition of spheroid formation, when confluent monolayers are exposed to microgravity. The evidence is based on proteins detected in cells and their supernatants of the recent spaceflight experiment: "NanoRacks-CellBox-Thyroid Cancer". The culture supernatant had been collected in a special container adjacent to the flight hardware incubation chamber and stored at low temperature until it was analyzed by Multi-Analyte Profiling (MAP) technology, while the cells remaining in the incubation chamber were fixed by RNAlater and examined by mass spectrometry. The soluble proteins identified by MAP were investigated in regard to their mutual interactions and their influence on proteins, which were associated with the cells secreting the soluble proteins and had been identified in a preceding study. A Pathway Studio v.11 analysis of the soluble and cell-associated proteins together with protein kinase C alpha (PRKCA) suggests that caveolin-1 is involved, when plasminogen enriched in the extracellular space is not activated and the vascular cellular adhesion molecule (VCAM-1) mediated cell–cell adhesion is simultaneously strengthened and activated PRKCA is recruited in caveolae, while the thyroid cancer cells do not form spheroids.
from #Medicine via ola Kala on Inoreader http://ift.tt/1l1z6XQ
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 30
(74)
- Cost effectiveness of personalized treatment in wo...
- Symptomatic small schwannoma is a risk factor for ...
- Lymphocyte subpopulations in myocardial infarction...
- The demographics of patients affected by surgical ...
- How welcome do Iranian-Americans feel in their hom...
- Multi technique amalgamation for enhanced informat...
- Cloning and transcriptional expression of a novel ...
- On a conjecture of R. Brück and some linear differ...
- Three drugs vs two drugs first-line chemotherapy r...
- The Nobel Prize 2015: The fight against parasitic ...
- Editorial Board
- Major advances in physiology: celebrating a centen...
- Factoring in weather variation to capture the infl...
- Recorded gonorrhoea rates in Denmark, 1900-2010: t...
- Depression and anxiety in ovarian cancer: a system...
- Incidence of knee cartilage surgery in Norway, 200...
- Vitamin D status and associated metabolic risk fac...
- Organisation and function of the primary motor cor...
- Identification of antithrombotic drugs related to ...
- Patient experience of computerised therapy for dep...
- Home oxygen therapy reduces risk of hospitalisatio...
- Association between sleeping hours and cardiometab...
- Preventing obesity in infants: the Growing healthy...
- Nutrition interventions for children aged less tha...
- Gene expression signatures, pathways and networks ...
- Platelet transfusions in cancer patients with hypo...
- Infective endocarditis requiring ICU admission: ep...
- Bounding the per-protocol effect in randomized tri...
- Multi Tonal Tinnitus
- Improving the organisation of maternal health serv...
- Comparison of treatment outcomes of endoscope-guid...
- Gonadotropins facilitate potential differentiation...
- Association of HLA and cytokine gene polymorphisms...
- Guidelines for cytopathologic diagnosis of epithel...
- Collagenous spherulosis: An interesting cytologica...
- Pitfall in immunohistochemical staining for thyrog...
- Geomagnetic Field (Gmf) and Plant Evolution: Inves...
- Analysis of Zebrafish Larvae Skeletal Muscle Integ...
- Rapid Fractionation and Isolation of Whole Blood C...
- An emerging concern: Toxic fumes in airplane cabins
- Normal-Weight Central Obesity and Mortality
- Notice of Retraction: Ramipril Markedly Improves W...
- Sofosbuvir With Velpatasvir in Treatment-Naive Non...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Normal-Weight Central Obesity: Implications for To...
- Revelation
- Behavioral Programs for Type 1 Diabetes Mellitus A...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Behavioral Programs for Type 2 Diabetes Mellitus A...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Applied Sciences, Vol. 5, Pages 1440-1456: 2D Satu...
- IJMS, Vol. 16, Pages 28334-28346: Carbon Ion Irrad...
- Animals, Vol. 5, Pages 1207-1219: A Review of Diff...
- IJMS, Vol. 16, Pages 28320-28333: Gene Expression ...
- Molecules, Vol. 20, Pages 21204-21213: Metabolic C...
- IJMS, Vol. 16, Pages 28311-28319: RpoN Regulates V...
- Animals, Vol. 5, Pages 1220-1232: Artificially Inc...
- Molecules, Vol. 20, Pages 21232-21253: Hydrotherma...
- IJERPH, Vol. 12, Pages 15129-15142: Feasibility of...
- Sensors, Vol. 15, Pages 29882-29892: Identificatio...
- IJERPH, Vol. 12, Pages 15075-15087: A Comparative ...
- Sensors, Vol. 15, Pages 29871-29881: Temperature E...
- IJERPH, Vol. 12, Pages 15118-15128: Epidemiology o...
- IJMS, Vol. 16, Pages 28296-28310: The Importance o...
- IJERPH, Vol. 12, Pages 15110-15117: Occurrence and...
- IJERPH, Vol. 12, Pages 15143-15153: The Geographic...
- IJERPH, Vol. 12, Pages 15100-15109: Assessment of ...
- IJERPH, Vol. 12, Pages 15088-15099: The Associatio...
- IJERPH, Vol. 12, Pages 15058-15074: Healthy versus...
- Sensors, Vol. 15, Pages 29893-29909: Improved PPP ...
- Knowledge, Attitudes, and Usage of Apitherapy for ...
- Sensors, Vol. 15, Pages 29855-29870: Electromagnet...
- Sensors, Vol. 15, Pages 29841-29854: Enhanced Two-...
- Sensors, Vol. 15, Pages 29821-29840: Process Minin...
-
▼
Νοε 30
(74)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 30 Νοεμβρίου 2015
IJMS, Vol. 16, Pages 28296-28310: The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.