Background: The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effect may be estimated under more plausible assumptions. Strategies for obtaining bounds, known as "partial identification" methods, are especially promising in randomized trials. Results: We estimated bounds for the per-protocol effect of colorectal cancer screening in the Norwegian Colorectal Cancer Prevention trial, a randomized trial of one-time sigmoidoscopy screening in 98,792 men and women aged 50–64 years. The screening was not available to the control arm, while approximately two thirds of individuals in the treatment arm attended the screening. Study outcomes included colorectal cancer incidence and mortality over 10 years of follow-up. Without any assumptions, the data alone provide little information about the size of the effect. Under the assumption that randomization had no effect on the outcome except through screening, a point estimate for the risk under no screening and bounds for the risk under screening are achievable. Thus, the 10-year risk difference for colorectal cancer was estimated to be at least −0.6 % but less than 37.0 %. Bounds for the risk difference for colorectal cancer mortality (–0.2 to 37.4 %) and all-cause mortality (–5.1 to 32.6 %) had similar widths. These bounds appear helpful in quantifying the maximum possible effectiveness, but cannot rule out harm. By making further assumptions about the effect in the subpopulation who would not attend screening regardless of their randomization arm, narrower bounds can be achieved. Conclusions: Bounding the per-protocol effect under several sets of assumptions illuminates our reliance on unverifiable assumptions, highlights the range of effect sizes we are most confident in, and can sometimes demonstrate whether to expect certain subpopulations to receive more benefit or harm than others.Trial registrationClinicaltrials.gov identifier NCT00119912 (registered 6 July 2005)
from #Medicine via ola Kala on Inoreader http://ift.tt/1TpIlMB
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 30
(74)
- Cost effectiveness of personalized treatment in wo...
- Symptomatic small schwannoma is a risk factor for ...
- Lymphocyte subpopulations in myocardial infarction...
- The demographics of patients affected by surgical ...
- How welcome do Iranian-Americans feel in their hom...
- Multi technique amalgamation for enhanced informat...
- Cloning and transcriptional expression of a novel ...
- On a conjecture of R. Brück and some linear differ...
- Three drugs vs two drugs first-line chemotherapy r...
- The Nobel Prize 2015: The fight against parasitic ...
- Editorial Board
- Major advances in physiology: celebrating a centen...
- Factoring in weather variation to capture the infl...
- Recorded gonorrhoea rates in Denmark, 1900-2010: t...
- Depression and anxiety in ovarian cancer: a system...
- Incidence of knee cartilage surgery in Norway, 200...
- Vitamin D status and associated metabolic risk fac...
- Organisation and function of the primary motor cor...
- Identification of antithrombotic drugs related to ...
- Patient experience of computerised therapy for dep...
- Home oxygen therapy reduces risk of hospitalisatio...
- Association between sleeping hours and cardiometab...
- Preventing obesity in infants: the Growing healthy...
- Nutrition interventions for children aged less tha...
- Gene expression signatures, pathways and networks ...
- Platelet transfusions in cancer patients with hypo...
- Infective endocarditis requiring ICU admission: ep...
- Bounding the per-protocol effect in randomized tri...
- Multi Tonal Tinnitus
- Improving the organisation of maternal health serv...
- Comparison of treatment outcomes of endoscope-guid...
- Gonadotropins facilitate potential differentiation...
- Association of HLA and cytokine gene polymorphisms...
- Guidelines for cytopathologic diagnosis of epithel...
- Collagenous spherulosis: An interesting cytologica...
- Pitfall in immunohistochemical staining for thyrog...
- Geomagnetic Field (Gmf) and Plant Evolution: Inves...
- Analysis of Zebrafish Larvae Skeletal Muscle Integ...
- Rapid Fractionation and Isolation of Whole Blood C...
- An emerging concern: Toxic fumes in airplane cabins
- Normal-Weight Central Obesity and Mortality
- Notice of Retraction: Ramipril Markedly Improves W...
- Sofosbuvir With Velpatasvir in Treatment-Naive Non...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Normal-Weight Central Obesity: Implications for To...
- Revelation
- Behavioral Programs for Type 1 Diabetes Mellitus A...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Behavioral Programs for Type 2 Diabetes Mellitus A...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Applied Sciences, Vol. 5, Pages 1440-1456: 2D Satu...
- IJMS, Vol. 16, Pages 28334-28346: Carbon Ion Irrad...
- Animals, Vol. 5, Pages 1207-1219: A Review of Diff...
- IJMS, Vol. 16, Pages 28320-28333: Gene Expression ...
- Molecules, Vol. 20, Pages 21204-21213: Metabolic C...
- IJMS, Vol. 16, Pages 28311-28319: RpoN Regulates V...
- Animals, Vol. 5, Pages 1220-1232: Artificially Inc...
- Molecules, Vol. 20, Pages 21232-21253: Hydrotherma...
- IJERPH, Vol. 12, Pages 15129-15142: Feasibility of...
- Sensors, Vol. 15, Pages 29882-29892: Identificatio...
- IJERPH, Vol. 12, Pages 15075-15087: A Comparative ...
- Sensors, Vol. 15, Pages 29871-29881: Temperature E...
- IJERPH, Vol. 12, Pages 15118-15128: Epidemiology o...
- IJMS, Vol. 16, Pages 28296-28310: The Importance o...
- IJERPH, Vol. 12, Pages 15110-15117: Occurrence and...
- IJERPH, Vol. 12, Pages 15143-15153: The Geographic...
- IJERPH, Vol. 12, Pages 15100-15109: Assessment of ...
- IJERPH, Vol. 12, Pages 15088-15099: The Associatio...
- IJERPH, Vol. 12, Pages 15058-15074: Healthy versus...
- Sensors, Vol. 15, Pages 29893-29909: Improved PPP ...
- Knowledge, Attitudes, and Usage of Apitherapy for ...
- Sensors, Vol. 15, Pages 29855-29870: Electromagnet...
- Sensors, Vol. 15, Pages 29841-29854: Enhanced Two-...
- Sensors, Vol. 15, Pages 29821-29840: Process Minin...
-
▼
Νοε 30
(74)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 30 Νοεμβρίου 2015
Bounding the per-protocol effect in randomized trials: an application to colorectal cancer screening
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.