Publication date: Available online 30 November 2015
Source:The Kaohsiung Journal of Medical Sciences
Author(s): Hai-Ping Zhang, Jian Zou, Ping Xie, Fei Gao, Hui-Jun Mu
Idiopathic pulmonary fibrosis (IPF) is a rare, progressive, and lethal interstitial lung disease with unknown etiology. Divergent observations have suggested that genetic factors contribute to IPF susceptibility. This study investigated the relationship between human leukocyte antigen (HLA), cytokine gene polymorphisms, and IPF in a Chinese Han population. The gene polymorphisms of HLA-A, -B, -DRB1, tumor necrosis factor alpha [TNF-α (−308 A/G)], transforming growth factor beta [TGF-β1 (+869 T/C)], interleukin 10 [IL-10 (−592 C/A, −819 T/C, and −1082 G/A)], and interferon gamma [IFN-γ (+874 T/A)] were detected in 102 individuals with IPF and 266 unrelated normal controls using PCR with sequence-specific primers and a high-resolution melt (HRM) approach. The data showed that there was no difference in HLA allele frequencies between the IPF and control groups. However, the data showed the frequency of HLA-A*02-DRB1*04 haplotype in the IPF group was significantly higher than that in the control group [odds ratio (OR) = 4.69, 95% confidence interval (CI) = 1.82–12.08, p < 0.001]. In addition, no differences in the allele and genotype distributions of the cytokines were found between the IPF and control groups (p > 0.01). Our findings suggest that there is an association between specific HLA haplotype and IPF genetic susceptibility and that the genetic variability of some cytokines may not be involved in the pathogenesis of IPF.
from #Medicine via ola Kala on Inoreader http://ift.tt/1lqQJzF
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 30
(74)
- Cost effectiveness of personalized treatment in wo...
- Symptomatic small schwannoma is a risk factor for ...
- Lymphocyte subpopulations in myocardial infarction...
- The demographics of patients affected by surgical ...
- How welcome do Iranian-Americans feel in their hom...
- Multi technique amalgamation for enhanced informat...
- Cloning and transcriptional expression of a novel ...
- On a conjecture of R. Brück and some linear differ...
- Three drugs vs two drugs first-line chemotherapy r...
- The Nobel Prize 2015: The fight against parasitic ...
- Editorial Board
- Major advances in physiology: celebrating a centen...
- Factoring in weather variation to capture the infl...
- Recorded gonorrhoea rates in Denmark, 1900-2010: t...
- Depression and anxiety in ovarian cancer: a system...
- Incidence of knee cartilage surgery in Norway, 200...
- Vitamin D status and associated metabolic risk fac...
- Organisation and function of the primary motor cor...
- Identification of antithrombotic drugs related to ...
- Patient experience of computerised therapy for dep...
- Home oxygen therapy reduces risk of hospitalisatio...
- Association between sleeping hours and cardiometab...
- Preventing obesity in infants: the Growing healthy...
- Nutrition interventions for children aged less tha...
- Gene expression signatures, pathways and networks ...
- Platelet transfusions in cancer patients with hypo...
- Infective endocarditis requiring ICU admission: ep...
- Bounding the per-protocol effect in randomized tri...
- Multi Tonal Tinnitus
- Improving the organisation of maternal health serv...
- Comparison of treatment outcomes of endoscope-guid...
- Gonadotropins facilitate potential differentiation...
- Association of HLA and cytokine gene polymorphisms...
- Guidelines for cytopathologic diagnosis of epithel...
- Collagenous spherulosis: An interesting cytologica...
- Pitfall in immunohistochemical staining for thyrog...
- Geomagnetic Field (Gmf) and Plant Evolution: Inves...
- Analysis of Zebrafish Larvae Skeletal Muscle Integ...
- Rapid Fractionation and Isolation of Whole Blood C...
- An emerging concern: Toxic fumes in airplane cabins
- Normal-Weight Central Obesity and Mortality
- Notice of Retraction: Ramipril Markedly Improves W...
- Sofosbuvir With Velpatasvir in Treatment-Naive Non...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Normal-Weight Central Obesity: Implications for To...
- Revelation
- Behavioral Programs for Type 1 Diabetes Mellitus A...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Behavioral Programs for Type 2 Diabetes Mellitus A...
- Treatment of Myalgic Encephalomyelitis/Chronic Fat...
- Applied Sciences, Vol. 5, Pages 1440-1456: 2D Satu...
- IJMS, Vol. 16, Pages 28334-28346: Carbon Ion Irrad...
- Animals, Vol. 5, Pages 1207-1219: A Review of Diff...
- IJMS, Vol. 16, Pages 28320-28333: Gene Expression ...
- Molecules, Vol. 20, Pages 21204-21213: Metabolic C...
- IJMS, Vol. 16, Pages 28311-28319: RpoN Regulates V...
- Animals, Vol. 5, Pages 1220-1232: Artificially Inc...
- Molecules, Vol. 20, Pages 21232-21253: Hydrotherma...
- IJERPH, Vol. 12, Pages 15129-15142: Feasibility of...
- Sensors, Vol. 15, Pages 29882-29892: Identificatio...
- IJERPH, Vol. 12, Pages 15075-15087: A Comparative ...
- Sensors, Vol. 15, Pages 29871-29881: Temperature E...
- IJERPH, Vol. 12, Pages 15118-15128: Epidemiology o...
- IJMS, Vol. 16, Pages 28296-28310: The Importance o...
- IJERPH, Vol. 12, Pages 15110-15117: Occurrence and...
- IJERPH, Vol. 12, Pages 15143-15153: The Geographic...
- IJERPH, Vol. 12, Pages 15100-15109: Assessment of ...
- IJERPH, Vol. 12, Pages 15088-15099: The Associatio...
- IJERPH, Vol. 12, Pages 15058-15074: Healthy versus...
- Sensors, Vol. 15, Pages 29893-29909: Improved PPP ...
- Knowledge, Attitudes, and Usage of Apitherapy for ...
- Sensors, Vol. 15, Pages 29855-29870: Electromagnet...
- Sensors, Vol. 15, Pages 29841-29854: Enhanced Two-...
- Sensors, Vol. 15, Pages 29821-29840: Process Minin...
-
▼
Νοε 30
(74)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 30 Νοεμβρίου 2015
Association of HLA and cytokine gene polymorphisms with idiopathic pulmonary fibrosis
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.