A common characteristic of many cancer cells is that they suffer from oxidative stress. They, therefore, require effective redox regulatory systems to combat the higher levels of reactive oxygen species that accompany accelerated growth compared to the normal cells of origin. An elevated dependence on these systems in cancers suggests that targeting these systems may provide an avenue for retarding the malignancy process. Herein, we examined the redox regulatory systems in human liver and lung cancers by comparing human lung adenocarcinoma and liver carcinoma to their respective surrounding normal tissues. Significant differences were found in the two major redox systems, the thioredoxin and glutathione systems. Thioredoxin reductase 1 levels were elevated in both malignancies, but thioredoxin was highly upregulated in lung tumor and only slightly upregulated in liver tumor, while peroxiredoxin 1 was highly elevated in lung tumor, but downregulated in liver tumor. There were also major differences within the glutathione system between the malignancies and their normal tissues. The data suggest a greater dependence of liver on either the thioredoxin or glutathione system to drive the malignancy, while lung cancer appeared to depend primarily on the thioredoxin system.
from #Medicine via ola Kala on Inoreader http://ift.tt/1RKoPZW
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 10
(50)
- Sensors, Vol. 15, Pages 28271-28286: Real-Valued C...
- Remote Sensing, Vol. 7, Pages 14988-15013: A Compa...
- A qualitative evidence synthesis on the management...
- Adherence to competing strategies for colorectal c...
- Lateral approach liver hanging maneuver in laparos...
- Meta-analysis of laparoscopic surgery for recurren...
- Identification of novel anti-hepatitis C virus age...
- Angiogenesis and vascular endothelial growth facto...
- Dexmedetomidine versus morphine infusion following...
- Tripterygium wilfordii hook F as maintenance treat...
- Variation in treatment priorities for chronic hepa...
- Randomized comparison of surveillance intervals in...
- Positive regulation of β-catenin–PROX1 signaling a...
- Prognostic factors for progression-free and overal...
- Prospective cohort study comparing transient EUS g...
- Palliative chemotherapy for patients 70 years of a...
- Influence of the intervention of exercise on obese...
- Characteristics of colonoscopic findings in the ve...
- Changes in insulin sensitivity and secretion after...
- Prevalence of pathogenic mutations in cancer predi...
- Current status of immunomodulatory therapy in chro...
- Blunting of colon contractions in diabetics with g...
- Family physicians’ intention to support women in m...
- Sharp-Hook Acupuncture (Feng Gou Zhen) for Patient...
- Cross-Sectional Study of Respiratory Symptoms, Spi...
- JFMK, Vol. 1, Pages 16-29: Clinical Kinesiology an...
- Insects, Vol. 6, Pages 943-960: Mating Success, Lo...
- Genes, Vol. 6, Pages 1201-1214: Identification of ...
- Graded Resistance Exercise And Type 2 Diabetes in ...
- Effect of a high-dose target-controlled naloxone i...
- Automated analysis of single cells using Laser Twe...
- Information, Vol. 6, Pages 733-749: Digital Inform...
- IJMS, Vol. 16, Pages 26880-26913: Therapeutic Impl...
- IJMS, Vol. 16, Pages 26871-26879: Identification o...
- IJMS, Vol. 16, Pages 26850-26870: Augmenting the A...
- Inorganics, Vol. 3, Pages 500-510: Holmium(III) Su...
- IJMS, Vol. 16, Pages 26880-26913: Therapeutic Impl...
- IJMS, Vol. 16, Pages 26871-26879: Identification o...
- IJMS, Vol. 16, Pages 26850-26870: Augmenting the A...
- IJMS, Vol. 16, Pages 26832-26849: Single-Cell Isol...
- IJERPH, Vol. 12, Pages 14312-14326: Kinetics and M...
- IJERPH, Vol. 12, Pages 14301-14311: Exposure to Ai...
- IJERPH, Vol. 12, Pages 14285-14300: Arsenic and Ot...
- IJMS, Vol. 16, Pages 26832-26849: Single-Cell Isol...
- Drug Delivery Using Novel Biological and Synthetic...
- Exploring Clinical and Epidemiological Characteris...
- Changes of Plantar Pressure and Gait Parameters in...
- Senescence-Associated Changes in Proteome and O-Gl...
- Selection of the Strain Lactobacillus acidophilus ...
- Cancers, Vol. 7, Pages 2262-2276: Differences in R...
-
▼
Νοε 10
(50)
Αναζήτηση αυτού του ιστολογίου
Τρίτη 10 Νοεμβρίου 2015
Cancers, Vol. 7, Pages 2262-2276: Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.