Derma .Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) Antibiotics followed by anticonvulsants were the most frequently offending drugs.Correspondence Familial frontal fibrosing alopecia in two male families María L. Porriño‐Bustamante MD, MSc Elena García‐Lora MD, PhD Agustín Buendía‐Eisman MD, PhD Salvador Arias‐Santiago MD, PhD First published: 05 June 2019 https://doi.org/10.1111/ijd.14499

Clinicopathologic Challenge
Recurrent blisters with pain following thermal burn injury to left leg and foot
May Abiad BS  Mazen Kurban MD  Ossama Abbas MD
First published: 02 June 2019 https://doi.org/10.1111/ijd.14494

Correspondence
First case of cutaneous sarcoidosis within tattoos under durvalumab
Perrine M. Rousseau MD  Judith Raimbourg MD  Marie Robert MD  Delphine Dansette MD  Brigitte Dréno PhD  Lucie Peuvrel MD … See all authors
First published: 04 June 2019 https://doi.org/10.1111/ijd.14484

Clinical Trial
Insomnia and other sleep complaints in inflammatory versus noninflammatory skin disorders: An observational case‐control study
Ladan Mostaghimi MD  Scott Hetzel MS
First published: 05 June 2019 https://doi.org/10.1111/ijd.14488
Collaborators: Ruth Benca, MD; Diane Bock BS; Sandra R. Olson BS, MPH; Michael R. Hetzer BS, HT (ASCP); David Puchalsky, MD; Rita Lloyd, MD (University of Wisconsin Madison).
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Abstract
Background
Sleep problems are common in patients with dermatologic disorders. However, it is unknown whether inflammatory skin disorders are associated with more sleep problems than noninflammatory skin disorders.

Purpose
To determine whether sleep problems occur more frequently in people with inflammatory skin disorders compared to noninflammatory skin disorders.

Study design
Observational case‐control study.

Methods
Patients with inflammatory skin disorders (psoriasis [n = 17] and chronic eczema [n = 30]) and noninflammatory skin disorders (nonmelanoma skin cancers [NMSC] [n = 31]) were enrolled. Data collection occurred during a single visit. Statistical analysis of questionnaire results between groups utilized inverse propensity score weighted (IPSW) ANOVA and logistic regression models.

Results
Groups differed in mean (SD) age (P < 0.001) and itch severity (P < 0.001). Based on IPSW ANOVA models, the inflammatory group had significantly higher fatigue scores (mean [95% CI]; 32.0 [28.4–35.5]) than the noninflammatory group (25.5 [21.6–29.3]; P = 0.017). The inflammatory group odds of insomnia were significantly greater based on two definitions of insomnia, ISI ≥ 15 and PSSQ‐I, with odds ratios (95% CI) of 14.4 (2.16–525) and 4.82 (1.45–20.7), respectively. These results were consistent in comparisons between the three groups, with no difference between psoriasis and chronic eczema, but with chronic eczema, significantly more were affected than NMSC.

Conclusions
Patients with inflammatory skin disorders report significantly more fatigue and have higher odds of insomnia compared to patients with noninflammatory skin cancers.

Clinicopathologic Challenge
Asymptomatic skin‐colored papule on the upper eyelid in a young man
Nandhini Periasamy MBBS  Geeti Khullar MD, DNB  Shruti Sharma DNB
First published: 05 June 2019 https://doi.org/10.1111/ijd.14522

Correspondence
Acquired localized ichthyosis in mixed connective tissue disease: a predictor of underlying sclerotic disease?
Hernán A. Feola MD  Ramiro Luna Cian MD  Daniel Morgado‐Carrasco MD
First published: 05 June 2019 https://doi.org/10.1111/ijd.14524

Correspondence
Adherence to the Mediterranean diet is independently associated with psoriasis risk, severity, and quality of life: a cross‐sectional observational study
Anastasia Korovesi MSc  Maria Dalamaga MD, PhD  Marianna Kotopouli MSc  Evangelia Papadavid MD, PhD
First published: 05 June 2019 https://doi.org/10.1111/ijd.14523

Report
Stevens‐Johnson syndrome and toxic epidermal necrolysis: a retrospective descriptive study
Osward Y. Carrasquillo MD, MPH  Marely Santiago‐Vazquez MD  Rocio Cardona MD  Mariana Cruz‐Manzano MD  Luz D. Figueroa MD
First published: 05 June 2019 https://doi.org/10.1111/ijd.14493
Conflict of interest: The authors have no conflict of interest to disclose.
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Abstract
Background
Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and potentially life‐threatening mucocutaneous reactions. Given their rarity, limited cohort studies have been done. The aim of this study is to evaluate and compare the demographics, etiology, management, clinical and laboratory characteristics, complications, and outcome of SJS/TEN patients seen by the inpatient dermatology service at the University of Puerto Rico.

Methods
A retrospective review of 30 cases with identified diagnosis of SJS, overlap SJS/TEN, or TEN who were consulted to the Dermatology Department of the University of Puerto Rico from 2006 to 2017.

Results
A total of 24 adult and six pediatric cases were reviewed. Females were predominant with a female to male ratio of 1.3 : 1. The most frequent offending drugs identified were antibiotics (56.7%), anticonvulsants (23.3%), and nonsteroidal anti‐inflammatory drugs (NSAIDs) (16.7%) with the most frequent antibiotic identified being trimethoprim/sulfamethoxazole (23.3%). Seventy percent of patients experienced at least one complication, most often of infectious etiology (80.1%). During hospital course, 73% received pharmacologic therapy (23% received IVIG alone, 17% received steroids alone, and 33% both) versus 27% which received only supportive care. Mortality rate in this study was 13.8%. When comparing SCORTEN at day one of admission, deceased cases had a mean SCORTEN at day 1 of 4.0, while survivors had an average of 1.54 (P < 0.001).

Conclusion
Antibiotics followed by anticonvulsants were the most frequently offending drugs identified within this study.

Correspondence
Familial frontal fibrosing alopecia in two male families
María L. Porriño‐Bustamante MD, MSc  Elena García‐Lora MD, PhD  Agustín Buendía‐Eisman MD, PhD Salvador Arias‐Santiago MD, PhD
First published: 05 June 2019 https://doi.org/10.1111/ijd.14499

Correspondence
Pinch purpura unmasking systemic amyloidosis
Zoe Apalla PhD  Theocharis‐Nektarios Kirtsios  Eirini Katodritou PhD  Aimilios Lallas PhD  Dimitrios Konstantinou PhD  Theodoros Karamitsos PhD
First published: 07 June 2019 https://doi.org/10.1111/ijd.14552

Commentary
Programmed cell death protein 1 and vitiligo
Xiran Lin MD  Xianmin Meng MD  Zhiqi Song MD, PhD
First published: 07 June 2019 https://doi.org/10.1111/ijd.14542

Correspondence
Legal, medical, and ethical implications of instant messaging application use in dermatology
Davide Fattore MD  Mario Delfino MD  Gabriella Fabbrocini MD
First published: 07 June 2019 https://doi.org/10.1111/ijd.14519

Report
Stevens‐Johnson syndrome and toxic epidermal necrolysis – retrospective review of cases in a high complexity hospital in Brazil
Marcella P. Medeiros MD  Caroline H. C. Carvalho MD  Cláudia G. Santi MD  Joao Avancini MD
First published: 07 June 2019 https://doi.org/10.1111/ijd.14544
Funding sources: None.
Conflict of interest: None.
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Abstract
Background
Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare conditions characterized by epidermal necrosis, mostly caused by drugs. Despite the rarity of these conditions, morbidity and mortality are high (even in previously healthy patients), and they may be associated with permanent sequelae.

Methods
A retrospective study conducted at a quaternary hospital in Brazil in a period of 10 years.

Results
The sample was composed by 41 patients with SJS, SJS/TEN, and TEN confirmed by skin biopsy. Antibiotics and anticonvulsants were the most frequently implied drug classes, and phenytoin was the most important individual culprit drug. In this study, 12.2% of the patients had sequelae, being ophthalmological lesions the most common and one case of a newly described hearing loss. The mortality rate was 16.7% in patients with TEN.

Conclusions
This study describes the largest Latin American case series of SJS and TEN with the diagnosis proven by skin biopsy and adds important data regarding the profile of the disease in Brazil. It also describes a novel sequelae of hearing loss.

Clinicopathologic Challenge
Nodular skin lesions and geographic skin plaques over face and trunk
Sheetanshu Kumar MD  Divya Aggarwal MD  Bishan D. Radotra MD  Keshavamurthy Vinay MD
First published: 07 June 2019 https://doi.org/10.1111/ijd.14521

Letter to the Editor
Alopecia areata and sleep quality: is there an interaction?
E.M.S. Xerfan  M.L. Andersen  A.S. Facina  S. Tufik  J. Tomimori
First published: 23 May 2019 https://doi.org/10.1111/jdv.15705

Correspondence
Novel clinical features associated with Clouston syndrome
Francisco Cammarata-Scalisi MD  Martina Rinelli PhD  Elisa Pisaneschi MD  Andrea Diociauti MD, PhD Colin E. Willoughby MD, PhD  Andrea Avendaño PhD  Maria C. Digilio MD … See all authors
First published: 05 June 2019 https://doi.org/10.1111/ijd.14507

Clouston syndrome is a form of ectodermal dysplasia, a group of about 150 conditions characterized by abnormal development of some or all of the ectodermal structures, which include the skin, hair, nails, teeth, and sweat glands.
Clouston syndrome - Genetics Home Reference - NIH
https://ghr.nlm.nih.gov/condition/clouston-syndrome

Alexandros Sfakianakis
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