Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis

Zhou et al. find that during viral infection, liver-resident NK (LrNK) cells inhibit the function of hepatic T cells via PD-1-PD-L1 interactions. Their findings reveal a role for LrNK cells in the regulation of T cell immunity and provide insight into the mechanisms of immune tolerance in the liver.

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