FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration

Yan et al. switch a pair of nucleotides in FOXO3 and endow human vascular cells with the ability to resist senescence, stress, and tumorigenesis. This study demonstrates that activated FOXO3 contributes to the maintenance of vascular homeostasis, providing a strategy for the generation of higher-quality transplants for stem cell-based therapy.

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