Man With Persistent Rash

A 20-year-old man presented to the emergency department with widespread discrete pruritic rash that started 6 months before. The rash remained persistent, but new lesions continued to appear, and exacerbations were accompanied with swelling and redness of the older lesions, sometimes accompanied by bullae formation. The patient recalled receiving painkillers, including ibuprofen, dipyrone, and naproxen, on a regular basis for headaches. The rash flared several hours after ingestion of the medications.

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