Αρχειοθήκη ιστολογίου

Αναζήτηση αυτού του ιστολογίου

Τρίτη 22 Ιανουαρίου 2019

DS86760016, a leucyl-tRNA synthetase inhibitor, with activity against Pseudomonas aeruginosa [Experimental Therapeutics]

DS86760016 is a new leucyl-tRNA-synthetase inhibitor in the preclinical development stage. DS86760016 showed potent activity against extended spectrum multidrug-resistant Pseudomonas aeruginosa isolated from clinical samples and in-vitro biofilms. In a murine catheter associated urinary tract infection model, DS86760016 treatment resulted in significant eradication of P. aeruginosa counts from kidney, bladder and catheter without developing drug-resistance. Our data suggest that DS86760016 has the potential to act as a new drug for the treatment of Pseudomonas infections.



http://bit.ly/2W81avP

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.