Depression stresses the immune response and promotes prostate cancer growth

Depression induces secretion of neuropeptide Y from prostate cancer cells which, in turn, recruits MDSCs to the tumor; tumor cells and MDSC secrete IL-6, which activates STAT3 within cancer cells. Prostate cancer samples from depressed patients reveal a similar phenotype, suggesting new treatment strategies based upon blockade of β2 adrenergic receptors and/or neuropeptide Y.

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