Sub-castrate testosterone nadir and clinical outcomes in intermediate or high-risk localized prostate cancer

Serum testosterone suppression below 20 ng/dL compared to 20-49 ng/dL was associated with improved PSA responses and lower rates of biochemical recurrence and metastasis in a cohort of intermediate- or high-risk prostate cancer patients treated with androgen deprivation and radiotherapy. This points to the potential need for closer monitoring of testosterone levels during androgen deprivation therapy for localized prostate cancer and could implicate the use of newer ADT agents among patients with inadequate testosterone suppression.

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