Sofosbuvir and Ribavirin eradication of refractory hepatitis E in an immunosuppressed kidney transplant recipient

Abstract

Hepatitis E virus (HEV) infection is a self‐limited asymptomatic illness in immunocompetent patients, but may cause chronic infection in immunosuppressed, solid organ transplant recipients. Chronic HEV can result in aggressive inflammation and fibrosis, leading to cirrhosis in up to 10%(1). Current therapy has been limited to reducing immunosuppression and/or ribavirin which leads to viral clearance in 64‐74% of patients.

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