Isavuconazole in the Treatment of Coccidioidal Meningitis [Clinical Therapeutics]

Patients with coccidioidal meningitis require life-long antifungal therapy. Cumulative toxicity and lack of antifungal efficacy requires salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in 3/9 patients and stable disease confirmed in 6/9. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

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