We investigated the effects of rs9564966 G > A polymorphism on the clinical prognosis of 919 patients with gastric cancer in Chinese population. The results demonstrated that compared with GG genotype, patients with GA + AA genotypes had poorer outcomes, especially in the subgroups of tumor size >5 cm group, tumor site in Noncardia, tumor of intestinal type, T3/ T4 level depth of invasion, N1/N2/N3 level lymph node metastasis, no distant metastasis, III/IV level TNM stages , and no chemotherapy. Our findings suggested that the rs9564966 G > A polymorphism may be a potential biomarker to predict the prognosis of Chinese patients with gastric cancer.
Abstract
Two genomewide association studies on pancreatic cancer have identified a novel single‐nucleotide polymorphism of rs9564966 G > A on 13q22.1 region. However, the associations between the rs9564966 G > A polymorphism and the survival of Chinese patients with gastric cancer (GC) were unknown. In our present investigation, we adopted the Kaplan‐Meier plots, Cox regression analyses, and the log‐rank tests to explore the associations between rs9564966 G > A polymorphism and the prognosis of 911 Chinese patients with GC. Our results revealed that, compared with GG genotype, patients with GA + AA genotypes had poorer outcomes (HR = 1.348, 95% CI = 1.084‐1.675, P = 0.007), especially in the subgroups of age ≤60 years, male, nondrinker, tumor size >5 cm, tumor site in Noncardia, intestinal‐type tumor, T3/T4 level depth of invasion, N1/N2/N3 level lymph node metastasis, no distant metastasis, III/IV level TNM stages, and no chemotherapy. Our findings suggested that the rs9564966 G > A polymorphism may be a potential biomarker to predict the survival of Chinese patients with GC.
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