Unraveling the control of cell cycle periods during intestinal stem cell differentiation

During differentiation, intestinal stem cells (ISCs), a prototypical adult stem cell pool, become either secretory transit-amplifying cells (sTAs), which give rise to all secretory cell types, or absorptive transit amplifying cells (aTAs), which give rise to enterocytes. These cells exhibit distinct cell cycle dynamics: ISCs cycle with a period of 24 hrs, aTAs with a period of about 12 hrs, while sTAs arrest their cycle. The cell cycle dynamics of ISCs and their progeny are a systems level property that emerges from interactions between the cell cycle control machinery and multiple regulatory pathways.

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