Inorganic nitrate alleviates total body irradiation-induced systemic damage by decreasing reactive oxygen species levels

Conventional radiotherapy is a common strategy for treating cancer patients, but it can induce multiple organ damage. The effect of supplementation with inorganic nitrate, a novel radioprotectant, on systemic damage was evaluated in a mouse model of total body gamma irradiation. Inorganic nitrate delivery was shown to effectively prevent systemic irradiation-induced damage, and nitrate-mediated decreases in reactive oxygen species levels may contribute to this radioprotective effect.

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