Dual role of the C-terminal domain in osmosensing by bacterial osmolyte transporter ProP

ProP is a member of the major facilitator superfamily, a proton-osmolyte symporter, and an osmosensing transporter. ProP proteins share extended cytoplasmic carboxyl terminal domains (CTDs) implicated in osmosensing. The CTDs of the best characterized, Group A ProP orthologues terminate in sequences that form intermolecular, antiparallel α-helical coiled-coils (e.g. ProPEc, from Escherichia coli). Group B orthologues lack that feature (e.g. ProPXc, from Xanthomonas campestris). ProPXc was expressed and characterized in E.

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