Introducing proton track-end objectives in intensity modulated proton therapy optimization to reduce linear energy transfer and relative biological effectiveness in critical structures

Proton track-end objectives have been introduced in the optimization of intensity modulated proton therapy plans to reduce linear energy transfer (LET) and relative biological effectiveness (RBE) in critical structures. The method was evaluated for six patients, plans optimized with dose objectives were compared with plans optimized with dose and track-end objectives. Track-end objectives allow for LET and RBE reductions in critical structures, which potentially could reduce normal tissue toxicity, without compromising the physical target dose.

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