Preclinical Modeling of Image-Guided Craniospinal Irradiation for Very-High-Risk Medulloblastoma

Although craniospinal irradiation (CSI) is crucial in treating medulloblastoma, clinical medulloblastoma protocols have not been faithfully modeled in a preclinical setting. We used the Small Animal Radiation Research Platform to deliver fully-fractionated, image-guided CSI to mice bearing patient-derived orthotopic xenografts of very-high-risk medulloblastoma. The preclinical application of this protocol was well tolerated, significantly prolonged survival, and yielded differential dose responses across medulloblastoma subgroups.

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