Panchromoendoscopy Increases Detection of Polyps in Patients With Serrated Polyposis Syndrome

SPS, characterized by multiple and/or large proximal serrated lesions, increases risk of CRC. Chromoendoscopy increases detection of adenomas and serrated lesions in average-risk populations. International guidelines and expert groups recommend the use of chromoendoscopy for SPS patient surveillance, despite little evidence. In a randomized controlled study of patients with SPS, indigo carmine panchromoendoscopy detected 2-fold more serrated lesions than high-definition white-light endoscopy during surveillance colonoscopy of cleared colon. Chromoendoscopy should be considered as the standard of care for SPS surveillance, but studies are needed to determine the effects of this strategy on incidence of advanced neoplasia.

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