ARNT as a Novel Antifibrotic Target in CKD

Per-Arnt-Sim (PAS) domain proteins are involved in the regulation of cellular responses to environmental stresses such as hypoxia or exposure to polycyclic aromatic hydrocarbons. They furthermore participate in the regulation of circadian rhythm.1 The therapeutic targeting of PAS domain proteins is likely to affect the clinical practice of nephrology because multiple compounds that activate hypoxia-inducible factor (HIF) are currently in clinical development for the treatment of renal anemia.2,3 HIF, a heterodimeric PAS domain transcription factor, is a central mediator of cellular hypoxia responses and consists of an oxygen-sensitive α subunit and the constitutively expressed aryl hydrocarbon receptor (AHR) nuclear translocator (ARNT), also known as HIF-1β.

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