Treatment Approach and Outcomes in Infants with Localized Rhabdomyosarcoma: A Report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group

Infants (≤ 24 months old) enrolled on Children's Oncology Group ARST0331 and ARST0531 protocols were permitted to undergo individualized local therapy. This retrospective review assesses the treatment approach and outcomes for these infants. While local control, event-free survival, and overall survival did not differ from older children on these protocols, individualized therapy was associated with a lower 5-year event-free survival and double the rate of local failure compared to protocol-specified therapy.

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